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首页> 美国政府科技报告 >Safety of the Pandemic H1N1 Influenza Vaccine among Pregnant U.S. Military Women and Their Newborns.
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Safety of the Pandemic H1N1 Influenza Vaccine among Pregnant U.S. Military Women and Their Newborns.

机译：美国孕妇及其新生儿甲型H1N1流感疫苗的安全性。

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A pandemic influenza A virus (pH1N1) emerged in April 2009, preferentially affecting pregnant women and their fetuses. Data regarding the safety of pH1N1 vaccination on both maternal and fetal outcomes are important. Pregnancies and pH1N1 vaccination status were identified among active-duty US military women (October 2009-June 2010). Maternal and infant outcomes were assessed and compared with pregnant women vaccinated with seasonal influenza vaccine (October 2008-June 2009). There were 10,896 pregnancies exposed to pH1N1 vaccine. Rates of pregnancy loss, preeclampsia/eclampsia, and preterm labor were similar to rates seen among seasonal influenza vaccine-exposed pregnancies from the previous year. Analyses of the 9435 infants born as a result of these pregnancies revealed no differences in the rates of preterm birth, birth defects, fetal growth problems, or the male:female sex ratio compared with infants exposed to seasonal influenza vaccine during gestation. Rates of all outcomes were lower or similar to overall rates within the general population. There were no identified adverse pregnancy or infant health outcomes associated with pH1N1 vaccination during pregnancy noted among our cohort. These findings are important for determining the safety of pH1N1 vaccination and should be used to encourage increased vaccine coverage among pregnant women.

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