• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Effects of Non-Opioid Antitussives on Epileptiform Activity and NMDA Responses in Hippocampal and Olfactory Cortex Slices.
【24h】

Effects of Non-Opioid Antitussives on Epileptiform Activity and NMDA Responses in Hippocampal and Olfactory Cortex Slices.

机译：非阿片类镇咳药对海马和嗅皮层切片中癫痫样活动和NmDa反应的影响。

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Three commonly used antitussive compounds were tested for their ability to block epileptiform activity recorded extracellularly from hippocampal and olfactory cortex slices maintained in vitro. Antitussives were bath-applied to brain slices either before or after epileptiform activity was induced. Dextromethorphan (DM) prevented electrically evoked epileptiform afterdischarges and arrested spontaneous bursting induced by exposure to added NMDA or to Mg2+-free medium. In contrast, caramiphen (CM) and carbetapentane (CB) were effective against concentrations 10 times the effective concentration of CM, which has known cholinolytic activity. Our results suggest that all these antitussives exert their anticonvulsant action at the DM binding site. Neither cholinolytic activity nor antagonism of the NMDA receptor-channel complex appears to be necessary for antitussives to prevent or arrest epileptiform activity.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号