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Relationship between Vasoactive Intestinal Polypeptide and Whole-Body Sweat Rateduring Exercise

机译:血管活性肠肽与全身感冒运动的关系

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The purpose of this study was to examine the relationship between vasoactiveintestinal polypeptide (VIP) and sweat rate during exercise. Seven male volunteers performed one hour of exercise at 60% of their maximal oxygen uptake (VO2 max) in 15 degC, 25 degC, and 35 degC conditions. Vasoactive intestinal polypeptide, whole-body sweat rate, and forearm skin blood flow were measured during each condition. Sweat rate and delta VIP (postexercise value minus preexercise value) demonstrated a significant (p < 0.05) linear relationship, with r = 0.73. Forearm skin blood flow and VIP were also linearly related, with r = 0.46 (p < 0.05). These results support the hypothesis that active cutaneous vasodilation and sweat rate are physiologically linked via the co-release of acetylcholine and VIP at the eccrine sweat gland. Furthermore, these findings strongly suggest that VIP plays a role in the human thermoregulatory response to exercise in the heat.

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