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Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes.

机译：子孢子疫苗诱导遗传限制性T细胞从肝细胞中消除疟疾。

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The target of the CD8(+) T cell-dependent immunity that protects mice immunized with irradiation-attenuated malaria sporozoites has not been established. Immune BALB/c mice were shown to develop malaria-specific, CD8 T cell-dependent inflammatory infiltrates in their livers after challenge with Plasmodium berghei sporozoites. Spleen cells from immune BALB/c and C57BL/6 mice eliminated hepatocytes infected with the liver stage of P. berghei in vitro. The activity against infected hepatocytes is not inhibited by antibodies to interferon gamma and is not present in culture supernatants. It is genetically restricted, an indication that malaria antigens on the hepatocyte surface are recognized by immune T effector cells. Subunit vaccine development will require identification of the antigens recognized by these T cells and a method of immunization that induces such immunity. Keywords:Malaria; Plasmodium; Berghei; Sporozoites; Cytotoxic T Lymphocytes; T cells; Malaria; Liver stage; Reprints. (KT)

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Hoffman, S. L.; Isenbarger, D.; Long, G. W.; Sedegah, M.; Szarfman, A.;
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年度 1989
页码 1-5
总页数 5
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Malaria; Sporozoites; Vaccines; Antibodies; Antigens; Cells(Biology); Cytotoxin; Elimination; Identification; Immunity; Immunization; In vitro analysis; Interferon; Limitations; Liver; Lymphocytes; Mice; Plasmodium berghei; Reprints; Spleen; Surfaces; Hepatocytes; T lymphocytes;

机译：疟疾;子孢子;疫苗;抗体;抗原;细胞（生物学）;细胞毒素;消除;鉴定;免疫;免疫;体外分析;干扰素;限制;肝脏;淋巴细胞;小鼠;伯氏疟原虫;重印;脾脏;表面;肝细胞; T淋巴细胞;

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1. Protection against malaria by Plasmodium yoelii sporozoite surface protein 2 linear peptide induction of CD4+ T cell- and IFN-gamma-dependent elimination of infected hepatocytes. [J] . R Wang, Y Charoenvit, G Corradin, The journal of immunology . 1996,第9期

机译：通过约氏疟原虫子孢子表面蛋白2线性肽诱导CD4 + T细胞和IFN-γ依赖性消除感染的肝细胞来预防疟疾。
2. A genetically attenuated parasite vaccine does not require liver stage persistence to elicit sterile protective immunity against sporozoite-induced malaria in mice. [J] . Mikolajczak SA, Vaughan AM, Soliman JM, The Journal of Infectious Diseases . 2010,第8期

机译：基因减毒的寄生虫疫苗不需要肝阶段的持久性即可引发针对子孢子诱发的疟疾的无菌保护性免疫。
3. A Genetically Attenuated Parasite Vaccine Does Not Require Liver Stage Persistence to Elicit Sterile Protective Immunity against Sporozoite-Induced Malaria in Mice [J] . Sebastian A. Mikolajczak, Ashley M. Vaughan, Joanne M. B. Soliman Journal of Infectious Diseases . 2010,第8期

机译：基因减毒的寄生虫疫苗不需要肝脏阶段的持久性来诱发针对子孢子虫诱导的疟疾的无菌保护性免疫。
4. The Role of the Amino Acid Side Chain Residues in the Biological Action of Angiotensin II, Against the Malaria Sporozoites [C] . Adriana F. Silva, Ceres C. Maciel, Margareth de L. Capurro American Peptide Symposium . 2011

机译：氨基酸侧链残余物在血管紧张素II的生物作用中的作用，对抗疟疾孢子
5. Development of molecular genetic tools in Plasmodium berghei: Applications for in vivo analysis of protein function in malaria sporozoites. [D] . Thathy, Vandana. 2000

机译：伯氏疟原虫分子遗传工具的发展：疟疾子孢子体内蛋白质功能的体内分析应用。
6. T lymphocytes from mice immunized with irradiated sporozoites eliminate malaria from hepatocytes. [O] . S. L. Hoffman, D. Isenbarger, G. W. Long, 1990

机译：用受子孢子免疫的小鼠的T淋巴细胞消除了肝细胞中的疟疾。
7. A Genetically Attenuated Parasite Vaccine Does Not Require Liver Stage Persistence to Elicit Sterile Protective Immunity against Sporozoite‐Induced Malaria in Mice [O] . Sebastian A. Mikolajczak, Ashley M. Vaughan, Joanne M. B. Soliman, 2010

机译：遗传减毒的寄生虫疫苗不需要肝脏阶段持续，以引发针对小鼠的孢子菌诱导的疟疾的无菌保护免疫力
8. Irradiated Sporozoite Vaccine Induces HLA-B8-Restricted Cytotoxic T LymphocyteResponses against Two Overlapping Epitopes of the Plasmodium falciparum Sporozoite Surface Protein 2 [R] . Wizel, B., Houghten, R. A., Parker, K. C., 1995

机译：辐照子孢子疫苗诱导HLa-B8限制性细胞毒性T淋巴细胞对两种重叠的恶性疟原虫子孢子表面蛋白2重叠表位的响应

Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes.

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