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Effects of Estradiol and Progesterone on Rat Intestinal and Hepatic Phospholipase A Activity.

机译:雌二醇和孕酮对大鼠肠道和肝脏磷脂酶a活性的影响。

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Small intestine and liver play major roles in lipid and lipoprotein metabolism. Both organs contain high activities of phospholipase A, but little is known regarding the hormonal regulation of this enzyme in these tissues. In the present study, phospholipase A activity was measured in male rats treated with subcutaneous injections of 17 beta-estradiol or progesterone. Estradiol treatment (0.6 mg/day for 14 days) decreased intestinal and hepatic phospholipase A activities by 65% and 53%respectively. Administration of estradiol reduced the specific activity of the enzyme in both microsomal and cytosol fractions of the intestinal mucosa. In contrast to the effects of estradiol, progesterone administration (2 mg/day for 14 days) increased phospholipase A activity in intestinal and hepatic tissue by 2.4- and 2.1- fold, respectively. Sex hormones; Phospholipase A; Lipoproteins; Amnion; Chorioallantois; Corticotropin. (jes)

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