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Mass Spectral Investigations on Toxins. 3. Accurate Analysis and Quantitation of Macrocyclic Trichothecenes in Environmental, Fungal, Fermentation, and Brazilian Plant Samples by Gas Chromatographic/Negative Ion Chemical Ionizatio

机译：毒素的质谱研究。 3.气相色谱/负离子化学电离法对环境，真菌，发酵和巴西植物样品中大环单端孢菌素的准确分析和定量

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A general, sensitive Gas Chromatographic Negative Ion Chemical Ionization-Mass Spectrometric method of analysis was developed for accurately detecting and measuring several polar, thermally labile,toxic macrocyclic trichothecenes. The procedure involves the conversion of the molecules into their corresponding alcohols (Verrucarols) by alkaline hydrolysis, followed by the derivatization of the hydrolysates with heptafluorobutyrylimidazole and analysis by the gas chromatographic/mass spectrometric techniques under negative ion chemical inoization conditions. Using this procedure, trace quantities (0.25-2 micrograms) of several macrocyclic trichothecenes with different verrucarol and ester moieties were analyzed successfully with good precision. The method developed was applicable for the accurate analysis of at least low part-per-billion levels of these macrocyclic trichothecenes in real-life samples such as fungal products, fermentation broths, and plant samples. This is the first report describing the well-developed, sensitive, and applicable method for detecting and measuring these compounds in true samples. Keywords: Toxins; trichothecenes; Mycotoxins; Hydrolysis; Derivation; Chemical ionization; Gas chromatography; Mass spectrometry; Quantification; Analysis; Detection limits: Negative ions.

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Krishnamurthy, T.; Sarver, E. W.; Greene, S. L.; Jarvis, B. B.;
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年度 1987
页码 p.1-32
总页数 32
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Fungi; Toxins and antitoxins; Alkalinity; Hydrolysis; Conversion; Molecules; Esters; Fermentation; Soup; Gas chromatography; Mass spectra; Chemicals; Ionization; Detection; Limitations; Mass spectrometry; Anions; Gases; Sensitivity; Quantity; Sampling;

机译：真菌;毒素和抗毒素;碱度;水解;转化;分子;酯类;发酵;汤;气相色谱;质谱;化学品;电离;检测;限制;质谱;阴离子;气体;灵敏度;数量;取样;

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机译：毒素的质谱研究。 7.通过直接化学电离 - 质谱/质谱技术检测和精确定量巴西植物样品中大环单端孢菌素的量子图数量

Mass Spectral Investigations on Toxins. 3. Accurate Analysis and Quantitation of Macrocyclic Trichothecenes in Environmental, Fungal, Fermentation, and Brazilian Plant Samples by Gas Chromatographic/Negative Ion Chemical Ionizatio

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