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Interaction of Opiate and Phencyclidine Derivatives with the Acetylcholine Receptor

机译：阿片和苯环利定衍生物与乙酰胆碱受体的相互作用

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摘要

The purpose of this work was to define the structural and biochemical environment of the AChR/I and the relationship of drug structure to the resultant pharmacological response. A number of drugs were tested using both biochemical and electrophysiological tests. For the most part, compounds consisted of benzomorphan and phencyclidine analogs, with the benzomorphans being the more thoroughly tested. Several important portions of the benzomorphan structure were identified, and the results of varying substitutents suggested that hydrophobicity parameters were the most important determinants of binding affinity.

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作者
Oswald, R. E.;
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年度 1985
页码 p.1-32
总页数 32
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Acetylcholine; Cholinergic nerves; Drugs; Opium alkaloids; Molecular structure; Biochemistry; Electrophysiology; Hydrophobic properties; Interactions; Pharmacology; Response; Sense organs; Test methods;

机译：乙酰胆碱;胆碱能神经;药物;鸦片生物碱;分子结构;生物化学;电生理学;疏水性;相互作用;药理学;反应;感觉器官;试验方法;

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1. Interactions between 3-(Trifluoromethyl)-3-(m-((125)I)iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel. [J] . Gallagher MJ, Chiara DC, Cohen JB Molecular pharmacology. . 2001,第6期

机译：在Torpedo系列烟碱型乙酰胆碱受体离子通道中，3-（三氟甲基）-3-（间-（（（125）I）碘苯基）二氮嗪与丁卡因，苯环利定或组氨酸毒素之间的相互作用。
2. Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors. [J] . Gharagozloo P, Lazareno S, Popham A, Journal of Medicinal Chemistry . 1999,第3期

机译：季铵苯丙氨酸和苯丙氨酸衍生物与毒蕈碱乙酰胆碱受体的变构相互作用。
3. Structure-activity relationships of acetylcholine derivatives with Lucilia cuprina nicotinic acetylcholine receptor alpha 1 and alpha 2 subunits in chicken beta 2 subunit hybrid receptors in comparison with chicken nicotinic acetylcholine receptor alpha 4/ beta 2. [J] . Dederer H., Berger M., Meyer T., Insect Molecular Biology . 2013,第2期

机译：与鸡的烟碱乙酰胆碱受体α4 / beta 2相比，鸡胆碱β2亚基杂种受体中乙酰胆碱衍生物与Lucilia cuprina烟碱乙酰胆碱受体α1和α2亚基的构效关系。
4. BIOCHEMICAL INTERACTIONS OF PYRETHROIDS AND DDT-LIKE COMPOUNDS WITH THE ACETYLCHOLINE-RECEPTOR IONIC CHANNEL COMPLEX [C] . N.A. Mansour, S.M. Sherby, Zeinab Shaaban International Congress of Pesticide Chemistry . 1986

机译：拟除虫菊酯和DDT样化合物与乙酰胆碱 - 受体离子频道复合物的生化相互作用
5. Functional interactions of alpha4beta2*-type nicotinic acetylcholine receptors with GABAB autoreceptors and calcineurin . [D] . McClure-Begley, Tristan David. 2010

机译：alpha4beta2 *型烟碱乙酰胆碱受体与GABAB自身受体和钙调神经磷酸酶的功能相互作用。
6. Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane [O] . Edson X. Albuquerque, Ming-Cheng Tsai, Robert S. Aronstam, 1980

机译：苯环利定与乙酰胆碱受体和成电膜的离子通道相互作用
7. Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane [O] . Albuquerque, Edson X., Tsai, Ming-Cheng, Aronstam, Robert S., 1980

机译：苯环利定与乙酰胆碱受体和成电膜的离子通道相互作用
8. Interaction of Opiate and Phencyclidine Derivatives with the Acetylcholine Receptor. [R] . Oswald, R. E. 1985

机译：阿片和苯环利定衍生物与乙酰胆碱受体的相互作用。

Interaction of Opiate and Phencyclidine Derivatives with the Acetylcholine Receptor

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