首页> 美国政府科技报告 >Effects of Chronic Hyperoxia on the Cardiovascular Responses to Vasoative Compounds in the Rabbit
【24h】

Effects of Chronic Hyperoxia on the Cardiovascular Responses to Vasoative Compounds in the Rabbit

机译:慢性高氧对兔血管活性物质心血管反应的影响

获取原文

摘要

Hyperoxia has been shown to disrupt certain membrane bound enzyme systems within the pulmonary endothelium which are responsible for the metabolism of several endogeneous vasoactive compounds. This study evaluated whether the potential disruption of the angiotensin converting enzyme (ACE) and the prostaglandin dehydrogenase/reductase (PGDH/R) enzyme, as a consequence of chronic hyperoxia, would alter the activation/deactivation of the angiotensins (I and Ii) or prostaglandins and thereby alter their peripheral cardiovascular actions. Two groups of conscious, chronically catheterized rabbits, one group exposed to ambient air and the other group exposed to > 98% oxygen, were given bolus injections of angiotensin I, angiotensin II, prostaglandin E sub 2 sodium nitroprusside, and phenylephrine before and during extended exposure to air or oxygen. Basal mean arterial pressure decreased for both groups during the exposure. However, the normoxic and the hyperoxic basal mean arterial pressures were never significantly different from one another at any exposure point. Basal heart rate for the hyperoxic animals significantly increased during the exposure period while the basal heart rate for the normoxic group was unaltered.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号