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Human Monocyte Activation for Cytotoxicity against Intracellular Leishmania donovani Amastigotes: Induction of Microbicidal Activity by Interferon-Gamma

机译：人单核细胞激活对细胞内杜氏利什曼原虫无毒鞭毛体的细胞毒性：干扰素-γ诱导杀微生物活性

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Macrophages are pivotal cells in interactions of man and leishmania. Leishmanial disease results from intracellular infection of macrophages: parasitized cells are seen in smears or biopsy specimens of lesions; macrophages cultured in vitro support replication of parasites. Paradoxically, parasite destruction is also mediated by macrophages, which become highly cytotoxic after exposure to immune lymphocytes or their lymphokine (LK) products. The precise molecular mechanisms by which lymphocytes or LK induce macrophage activation for leishmanicidal activity, however, are not yet known. We analyzed interactions of leishmania amatigotes with human monocytes cultured in vitro as a nonadherent cell pellet. Leishmania donovani and L. Major replicated in freshly isolated monocytes. Monocytes treated with 200 IU/ml of the LK, human Interferon-gamma (IFN-gamma), destroyed tumor cells and L. donovani, but not L. major. Phorbol myristate acetate, endotoxic bacterial lipopolysaccharide, and recombinant human IFN-alpha and IFN-beta did not induce cytotoxicity.

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作者
Hoover, D. L.; Nacy, C. A.; Meltzer, M. S.;
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年度 1985
页码 p.1-14
总页数 14
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicity; Immunity; Monocytes; Leishmaniasis; Infectious diseases; Parasites; Interferon; Biopsy; Lesions; Exposure(General); Lymphocytes; In vitro analysis; Interactions; Leishmania; Cells(Biology); Mastigotes; Endotoxins; Lipopolysaccharides; Mutagens; Humans; Phago;

机译：毒性;免疫;单核细胞;利什曼病;传染病;寄生虫;干扰素;活组织检查;病变;暴露（一般）;淋巴细胞;体外分析;相互作用;利什曼原虫;细胞（生物学）;鞭毛;内毒素;脂多糖;致突变体;人类; phago;

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1. Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages. [J] . W Y Weiser, A Van Niel, S C Clark, The Journal of Experomental Medicine . 1987,第5期

机译：重组人粒细胞/巨噬细胞集落刺激因子激活人单核细胞衍生巨噬细胞对利什曼原虫的细胞内杀伤。
2. Immunomodulation in Human Dendritic Cells Leads to Induction of Interferon-Gamma Production by Leishmania donovani Derived KMP-11 Antigen via Activation of NF-kappaB in Indian Kala-Azar Patients [J] . Rajesh Chaudhary, Aay Amit, Anupam Yadav, BioMed research international . 2014,第3期

机译：人树突状细胞中的免疫调节作用，通过激活印度卡拉-阿扎尔病患者，通过激活NF-κB诱导利什曼原虫衍生的KMP-11抗原诱导干扰素-γ的产生。
3. Quantitative proteomic profiling of the promastigotes and the intracellular amastigotes of Leishmania donovani isolates identifies novel proteins having a role in Leishmania differentiation and intracellular survival [J] . BiyaniN., MadhubalaR. Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2012,第12期

机译：利什曼原虫分离体的前鞭毛体和胞内变形虫的定量蛋白质组学分析鉴定了在利什曼原虫分化和细胞内存活中起作用的新型蛋白质
4. A Novel Human Cytotoxic Cell Activation Factor with anti- Cancer Activity [C] . TAMARA SANDLER, ORI BRAITBARD, JOEL OHANA, Recent advances in clinical medicine . 2010

机译：具有抗癌活性的新型人细胞毒性细胞激活因子
5. Cellular and molecular analysis of the cytotoxic activity of interferon-gamma [D] . Feng, Gensheng 1990

机译：干扰素-γ的细胞毒性活性的细胞和分子分析
6. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine. [O] . H W Murray, B Y Rubin, C D Rothermel 1983

机译：淋巴因子刺激的人单核吞噬细胞杀死细胞内的利什曼原虫。干扰素-γ是活化淋巴因子的证据。
7. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine. [O] . Murray, H W, Rubin, B Y, Rothermel, C D 1983

机译：淋巴因子刺激的人单核吞噬细胞杀死细胞内的利什曼原虫。干扰素-γ是活化淋巴因子的证据。
8. Intracellular Destruction of Leishmania donovani and Leishmania tropica Amastigotes by Activated Macrophages: Dissociation of These Microbicidal Effector Activities in vitro [R] . Hockmeyer, W. T., Walters, D., Gore, R. W., 1984

机译：激活的巨噬细胞对杜氏利什曼原虫和利什曼原虫无鞭毛体的细胞内破坏：这些杀微生物效应物的体外解离

Human Monocyte Activation for Cytotoxicity against Intracellular Leishmania donovani Amastigotes: Induction of Microbicidal Activity by Interferon-Gamma

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