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Correlation of Mutagenic, Carcinogenic and Cocarcinogenic Effects of Chemical Substances. Granuloma Pouch Assay

机译：化学物质的致突变，致癌和致癌作用的相关性。肉芽肿袋检测

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The research project is concerned with the detection of premalignant and malignant cells induced in vivo in a novel assay system the granuloma pouch assay. Cells exposed to carcinogens in vivo can be studied for DNA damage, chromosomal aberrations, specific locus mutations and cell transformations. Various assays were developed to investigate the growth characteristics of normal, carcinogen-exposed and transformed granuloma pouch cells. These included: primary cloning efficiencies under optimal growth conditions, growth in serum deficient and calcium depleted media, growth in soft agar, growth in athymic mice and rats, growth with cocultured normal cells, growth under influence of growth factors. Phenotypic alterations investigated were the DNA-dispersion in individual cells and the appearance of calcium binding proteins. Furthermore the genotoxic/cytotoxic activity of asbestos fibers was investigated.

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Zbinden, G.; Maier, P.;
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年度 1985
页码 p.1-18
总页数 18
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Mutagens; Carcinogens; Granuloma; Neoplasms; Cells(Biology); Endothelium; Fibroblasts; Carcinogenesis; Bioassay; In vivo analysis; Cell division; Clones; Cultures(Biology); Deoxyribonucleic acids; Proteins; Calcium; Asbestos; Fibers; Toxicity;

机译：致突变物;致癌物;肉芽肿;肿瘤;细胞（生物学）;内皮;成纤维细胞;癌变;生物测定;体内分析;细胞分裂;克隆;培养物（生物学）;脱氧核糖核酸;蛋白质;钙;石棉;纤维;毒性;

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1. Do cocarcinogenic effects of ELF electromagnetic fields require repeated long-term interaction with carcinogens? Characteristics of positive studies using the DMBA breast cancer model in rats. [J] . Loscher W, Loscher W Bioelectromagnetics. . 2001,第8期

机译：ELF电磁场的致癌作用是否需要与致癌物反复长期相互作用？使用DMBA乳腺癌模型在大鼠中进行阳性研究的特征。
2. Possible cocarcinogenic effects of ELF electromagnetic fields may require repeated long-term interaction with known carcinogenic factors. [J] . Juutilainen J, Lang S, Rytomaa T Bioelectromagnetics. . 2000,第2期

机译：ELF电磁场的可能的致癌作用可能需要与已知的致癌因素反复长期相互作用。
3. Mutagenic activity of carcinogens detected in transgenic rodent mutagenicity assays at dose levels used in chronic rodent cancer bioassays. [J] . Schmezer P, Eckert C, Liegibel UM, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1998,第2期

机译：在转基因啮齿动物致突变性测定中，在慢性啮齿动物癌症生物测定中使用的剂量水平下检测到的致癌物的诱变活性。
4. Mutagenic effects on the fluorescence of tryptophan residues in bacteriophage T4 lysozyme: Correlation with dynamics [C] . Bruce S. Hudson, Danni Harris Fluorescence Science and Technology . 2000

机译：诱变对噬菌体T4溶菌酶中色氨酸残留物的荧光的诱变作用：与动力学相关的相关性
5. SOME EFFECTS OF A CHEMICAL CARCINOGEN AND OF CIGARETTE SMOKE CONDENSATE UPON HAMSTER CHEEK POUCH MUCOSA [D] . KENDRICK, FRANCIS JOSEPH -1

机译：化学致癌物和香烟烟雾冷凝物对仓鼠颊粘液的某些影响
6. IARC Monographs: The Evaluation of Carcinogenic Risk of Chemicals to Man. Volume 4: Some Aromatic Amines Hydrazine and Related Substances N-Nitroso Compounds and Miscellaneous Alkylating Agents Volume 5: Some Organochlorine Pesticides Assessment of the Carcinogenicity and Mutagenicity of Chemicals: Report of a WHO Scientific Group [O] . Richard Carter 1974

机译：IARC专着：化学品对人的致癌风险的评估。第4卷：某些芳香胺肼和相关物质N-亚硝基化合物和其他烷基化剂第5卷：某些有机氯农药评估化学品的致癌性和致突变性：WHO科学小组的报告
7. IARC Monographs: The Evaluation of Carcinogenic Risk of Chemicals to Man. Volume 4: Some Aromatic Amines, Hydrazine and Related Substances, N-Nitroso Compounds and Miscellaneous Alkylating Agents, Volume 5: Some Organochlorine Pesticides, Assessment of the Carcinogenicity and Mutagenicity of Chemicals: Report of a WHO Scientific Group [O] . Carter, Richard 1974

机译：IARC专着：《化学品对人的致癌风险的评估》。第4卷：某些芳香胺，肼和相关物质，N-亚硝基化合物和其他烷基化剂，第5卷：某些有机氯农药，评估化学品的致癌性和致突变性：WHO科学小组的报告

Correlation of Mutagenic, Carcinogenic and Cocarcinogenic Effects of Chemical Substances. Granuloma Pouch Assay

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