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首页> 外文期刊>Bioelectromagnetics. >Possible cocarcinogenic effects of ELF electromagnetic fields may require repeated long-term interaction with known carcinogenic factors.
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Possible cocarcinogenic effects of ELF electromagnetic fields may require repeated long-term interaction with known carcinogenic factors.

机译：ELF电磁场的可能的致癌作用可能需要与已知的致癌因素反复长期相互作用。

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摘要

Literature on cancer-related biological effects of extremely low frequency (ELF) magnetic fields (MF) is discussed in the light of the current understanding of carcinogenesis as a multistep process of accumulating mutations. Different animal models and study designs have been used to address possible cocarcinogenic effects of MFs. Based on a comparison of the results, we propose a hypothesis that MF exposure may potentiate the effects of known carcinogens only when both exposures are chronic. We also discuss possible mechanisms of MF effects on carcinogenesis and the adequacy of the classical two-step initiation/promotion animal experiments for simulating human exposure to the complex mixture of environmental carcinogens. We conclude that experiments designed according to the two-step concept may not be sufficient for studying the possible role of MF in carcinogenesis. Possible further animal studies are more likely to be productive if they include models that combine chronic exposure to MFs with long-term exposures to known carcinogens. Copyright 2000 Wiley-Liss, Inc.
机译：鉴于目前对致癌是累积突变的多步过程的理解，因此讨论了有关极低频（ELF）磁场（MF）的癌症相关生物学效应的文献。已经使用不同的动物模型和研究设计来解决MF可能的致癌作用。基于结果的比较，我们提出一个假设，即只有当两种暴露都是慢性时，MF暴露才可能增强已知致癌物的作用。我们还将讨论MF对致癌作用的可能机制，以及模拟人类暴露于环境致癌物复杂混合物的经典两步引发/促进动物实验的充分性。我们得出结论，根据两步概念设计的实验可能不足以研究MF在癌变中的可能作用。如果可能的进一步动物研究如果包含将长期暴露于MF的长期暴露与已知致癌物的长期暴露相结合的模型，则更有可能取得成果。版权所有2000 Wiley-Liss，Inc.

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