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Validation of Biomarkers Predictive of Recurrence Following Prostatectomy.

机译：生物标志物的验证预测前列腺切除术后的复发。

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To validate biomarkers of recurrence following radical prostatectomy. Scope: Perform genomic profiling of test and validation sets from formalin-fixed samples with longterm follow up data. Major Findings: We have published a manuscript in The American Journal of Pathology describing our set of biomarkers, and presented these data orally at the American Society of Investigative Pathology annual meeting in Washington, DC on April 11, 2011. We have optimized our method for RNA-seq analysis and collected 171 patient samples, of which 108 have passed RNA QC. We are in the process of preparing RNA-seq libraries and anticipate generating large datasets for analysis in the next few months. We have applied our published biomarkers to publicly available datasets and shown that they are predictive. We have demonstrated that four protein biomarkers (BID, SIM2s, FBP1, and RAD23B) are significantly associated with recurrence in prostate cancer. These immunohistochemistry assays may be useful for predicting recurrence in clinical cases.

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