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首页> 美国政府科技报告 >Plasma Levels of 6-Keto PGF(1a) But Not TxB(2) Increase in Rats with Peritonitis due to Cecal Ligation
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Plasma Levels of 6-Keto PGF(1a) But Not TxB(2) Increase in Rats with Peritonitis due to Cecal Ligation

机译：Cecal结扎引起腹膜炎大鼠血浆中6-Keto pGF（1a）但不是TxB（2）增加

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Acute, overwhelming sepsis or endotoxemia in experimental animals is associated with increased circulating levels of thromboxane (Tx)B2(stable metabolite of TxA2) and 6-Keto PGF sub 1A (stabe metabolite of prostacyclin). The purpose of the present investigation was to determine the plasma prostanoid response to septsi using an animal paradigm in whilch th e septic process evolved more slowly thatn in previous similar stuides. Bacterial peritonitis was induced in rats by cecal ligation(group B) or cecal ligation plus puncture with a 22-gauge needle (group C). Compared to sham-operated controls (group A), levels of immunoreactive 6-keto PGF sub 1a were significantly (p < .05) elevated in group C rats at 6, 12, and 24 hr after surgery. At 48 hr after surgery, levels of this prostanoid were significantly (p<.05) elevated in group B animals. In contrast, TxB2 levels were never significantly increased in septic (groups B and C) as compared to control (roup A) rats. These data are consistent with results from several clinical studies and emphasize and important difference between the cecal ligation model and other experimental sepsis paradigms.

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