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Clonal Analysis of HLA-DR and -DQ Associated Determinants - Their Contribution to Dw Specificities

机译：HLa-DR和-DQ相关决定因素的克隆分析 - 对Dw特异性的贡献

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In order to investigate the distribution of epitopes recognized by T cell clones directed against HLA class II products, bulk primed cell populations were generated using cells matched for class I determinants but disparate for class II determinants. Cells were cloned by single cell deposition (FACS IV) or limiting dilution (1 cell/3 wells), and assayed for proliferative and cytolytic function with panels of well-characterized cells. Our data indicate that determinants detected on both DR and DQ products are associated with the Dw type of the sensitizing cell showing that there is polymorphism recognized by T cells on both DR and DQ that is subtypic to the serologically defined specificities. Thus, it appears that the bulk T cell response is a composite of individual clones recognizing distinct determinants on these class II molecules. The implications of these findings for studies of HLA restricted recognition are discussed.

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Reinsmoen, N. L.; Bach, F. H.;
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年度 1985
页码 p.1-39
总页数 39
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Antigens; Clones; Lymphocytes; Genes; Serology; Response; Dilution; Limitations; Polymorphism; Sensitizing; Cells(Biology); Panels; Recognition; Deposition;

机译：抗原;克隆;淋巴细胞;基因;血清学;响应;稀释;限制;多态性;增敏;将细胞（生物）;面板;识别;沉积;

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2. Differences in the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Adult- and Childhood-Onset Type 1 Diabetes in Japanese Patients. [J] . Murao S, Makino H, Kaino Y, Diabetes . 2004,第10期

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机译：β链残基57对HLA-DR和-DQ分子的肽结合能力的关键贡献
4. OWA-PSSM #x2014; A position specific scoring matrix based method integrated with OWA weights for HLA-DR peptide binding prediction [C] . Shen Wen-Jun, Wong Hau-San 2012 IEEE International Conference on Bioinformatics and Biomedicine. . 2012

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Clonal Analysis of HLA-DR and -DQ Associated Determinants - Their Contribution to Dw Specificities

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