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Discovery and Synthesis of GS-5734, a Phosphoramidate Prodrug of a Pyrrolo[2,1 f][triazin-4-amino] Adenine C-Nucleoside for the Treatment of Ebola and Emerging Viruses.

机译：发现和合成Gs-5734，一种吡咯并[2,1 f] [三嗪-4-氨基]腺嘌呤C-核苷的氨基磷酸酯前药，用于治疗埃博拉病毒和新发病毒。

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年度 2017
页码 1-59
总页数 59
原文格式 PDF
正文语种 eng
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Ebola virus;

机译：伊波拉病毒;

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专利

1. Prodrugs of a 1 '-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV [J] . Mackman Richard L., Hui Hon C., Perron Michel, Journal of Medicinal Chemistry . 2021,第8期

机译：1'-cn-4-aza-7,9-dideazaadenosine c-核苷的前药导致雷德（GS-5734）作为呼吸道合胞病毒的有效抑制剂，其在RSV的非洲绿色猴子模型中具有疗效
2. Synthesis and Anti-HCV Activities of 4 '-Fluoro-2 '-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4 '-Fluoro-2 '-C-methyluridine 5 '-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection [J] . Wang Guangyi, Dyatkina Natalia, Prhavc Marija, Journal of Medicinal Chemistry . 2019,第9期

机译：4'-fluoro-2'-取代的尿苷三磷酸酯和核苷酸前药的合成和抗HCV活性：发现4'-氟-2'-C-甲基嘌呤5' - 磷酸盐的前药（Al-335）用于治疗肝炎 C感染
3. Synthesis and biological evaluation of novel pyrrolo(2,1-c)(1,4)benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy. [J] . Masterson LA, Spanswick VJ, Hartley JA, Bioorganic and Medicinal Chemistry Letters . 2006,第2期

机译：新型吡咯并（2,1-c）（1,4）苯并二氮杂pro前药的合成和生物学评价，用于抗体导向的酶前药治疗。
4. Discovery and Synthesisof a Phosphoramidate Prodrugof a Pyrrolo21-ftriazin-4-amino Adenine C-Nucleoside (GS-5734) for the Treatment of Ebolaand Emerging Viruses [O] . Dustin Siegel, Hon C. Hui, Edward Doerffler, -1

机译：发现与综合氨基磷酸酯前药吡咯并21-f 三嗪-4-氨基腺嘌呤C-核苷（GS-5734）治疗埃博拉病毒和新兴病毒
5. Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads [O] . Nadège Hamon, Magdalena Slusarczyk, Michaela Serpi, 2015

机译：两种类似物的两种类似物的磷酸氨基膦酸盐前药的合成与生物学评价，磷酸盐两种卡巴斯古菌作为新潜在抗艾滋病毒铅的发现

Discovery and Synthesis of GS-5734, a Phosphoramidate Prodrug of a Pyrrolo[2,1 f][triazin-4-amino] Adenine C-Nucleoside for the Treatment of Ebola and Emerging Viruses.

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