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首页> 美国政府科技报告 >Cellular IgE Response of Rodents to Infection with Nippostrongylus brasiliensis, Trichinella spiralis and Schistosoma mansoni
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Cellular IgE Response of Rodents to Infection with Nippostrongylus brasiliensis, Trichinella spiralis and Schistosoma mansoni

机译：啮齿动物对巴西日本血吸虫，旋毛虫和曼氏血吸虫感染的细胞IgE反应

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Inoculation of mice with infective larvae of the nematodes N. brasiliensis or T. spiralis and inoculation of rats with N. brasilienisis results in changes in the mesenteric lymph nodes draining the site of infection, that include a peak 3-4 fold increase in cell number between 11 and 15 days after infection, an increase in the total number of B cells, a corresponding decrease in the number of T cells, a marked increase in cells synthesizing IgE intracellularly and an increase in cells expressing IgE on their surface. Similar changes are evoked by a secondary infection of mice and rats with these nematode larvae. Inoculation of mice with cercariae of the trematode S. mansoni results in cellular changes in the mesenteric lymph nodes, as well as the spleen, that are comparable in degree to that of inoculation of mice with nimatode larvae. However, the peak of the response is not attained until several weeks after inoculation. The rodents host's cellular IgE response to infection with N. brasiliensis, T. spiralis and S. mansoni in the mesenteric lymph nodes and spleen is characterized by an increase in IgE synthesis, an increase in cell surface receptors for IgE, predominantly on B cell and the association of ambient IgE with B cell surface receptors. Adults stages of these helminthic parasites are apparently the major source of stimuli for the host's IgE response.

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