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首页> 外文期刊>Parasitology Research >Development of cellular immune response of mice to infection with low doses of Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis larvae.
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Development of cellular immune response of mice to infection with low doses of Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis larvae.

机译：小鼠对小剂量旋毛虫，旋毛虫和假旋毛虫幼虫感染的细胞免疫反应的发展。

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摘要

The murine cellular immune response to the infection with ten larvae of encapsulating (Trichinella spiralis, Trichinella britovi) and non-encapsulating species (Trichinella pseudospiralis) was studied. Both T. spiralis and T. britovi stimulated the proliferation of splenic T and B lymphocytes during the intestinal phase of infection, but T. spiralis activated the proliferative response also at the muscle phase, particularly in B cells. Non-encapsulating T. pseudospiralis stimulated the proliferation of T and B cells only on day 10 post-infection (p.i.) and later at the muscle phase. The numbers of splenic CD4 and CD8 T cells of T. spiralis infected mice were significantly increased till day 10 p.i., i.e., at the intestinal phase, and then at the late muscle phase, on day 60 p.i. T. britovi infection increased the CD4 and CD8 T cell numbers only on day 30 p.i. Decreased numbers of CD4 and CD8 T cells after T. pseudospiralis infection suggest a suppression of cellular immunity. Both encapsulating Trichinella species induced the Th2 response (cytokines interleukin-5 (IL-5) and interleukin-10) at the intestinal phase and the Th2 dominant response at the advanced muscle phase. Interferon-gamma (IFN-gamma) production (Th1 type) started to increase with migrating newborn larvae from day 15 p.i. till the end of the experiment. IL-5 production was suppressed during the intestinal phase of T. pseudospiralis infection. The immune response to T. pseudospiralis was directed more to the Th1 response at the muscle phase, the high IFN-gamma production was found on day 10 p.i. and it peaked on days 45 and 60 p.i.
机译：研究了鼠对十种包囊幼虫（旋毛虫，布里奇维氏梭菌）和非包囊物种（假旋毛虫）感染的免疫反应。在感染的肠道阶段，螺旋螺旋体和布里托螺旋体都刺激了脾脏的T和B淋巴细胞的增殖，但是螺旋螺旋体也在肌肉阶段，特别是在B细胞中也激活了增殖反应。非包囊假螺旋体仅在感染后第10天（p.i.）以及随后的肌肉阶段刺激T和B细胞的增殖。感染螺旋螺旋体的小鼠的脾脏CD4和CD8 T细胞的数量显着增加，直到p.i. 10天，即在肠道阶段，然后在肌肉后期，p.i 60天。布氏弧菌感染仅在p.i第30天才增加CD4和CD8 T细胞数量。假螺旋体感染后CD4和CD8 T细胞数量减少表明细胞免疫受到抑制。两种旋毛虫物种都在肠道阶段诱导Th2反应（细胞因子白细胞介素5（IL-5）和白细胞介素10），在晚期肌肉阶段诱导Th2显性反应。从出生后第15天开始，随着新生幼虫的迁移，干扰素-γ（IFN-γ）的产量（Th1型）开始增加。直到实验结束。在假螺旋体感染的肠道阶段，IL-5的产生受到抑制。对伪螺旋体的免疫反应更多地针对肌肉期的Th1反应，在p.i的第10天发现了高的IFN-γ产生。并在下午45和60天达到顶峰。

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