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首页> 美国政府科技报告 >Nonhuman Primate Models for the Study of Hemorrhagic Viral and Rickettsial Diseases.
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Nonhuman Primate Models for the Study of Hemorrhagic Viral and Rickettsial Diseases.

机译：用于研究出血性病毒和立克次体病的非人灵长类动物模型。

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A number of nonhuman primate models have been used for the study of hemorrhagic viral and rickettsial diseases. In terms of applicability to humans, data gained from model infectious diseases are conceptually more valid if obtained in nonhuman primates rather than in phylogenetically more distance species. In contrast to the problems encountered when trying to develop representative animal models for bacterial diseases, many of the hemorrhagic viral and ricketsial diseases of humans can be reproduced in one or more species of monkeys. In contrast to the varied monkey response to different pathogenic human viruses, the different pathogenic human rickettsiae seem consistent in their ability to produce overt disease in almost every monkey species in which they have been tried. Monkey models have been used primarily to demonstrate the occurrence of infection, to study the pathologic consequences of a terminal infection process, to document humoral antibody responses, and to test candidate vaccines. Relatively few details are known about subpopulations of lymphocytes or the complexities of cell-mediated immunity in monkey species in comparison to the depth of such knowledge currently available for mice or humans. Newer techniques have become available to obtain pulmonary alveolar macrophages repeatedly from a single monkey over the course of a lengthy study. Similarly, it is possible to obtain serial blood samples and temperature measures from an individual monkey by using a vest-tethering, which eliminates the need for repeated capture, handling, and sedation.

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