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首页> 美国政府科技报告 >Gastric Epithelioid Leiomyoma and Leiomyosarcoma (Leiomyoblastoma).
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Gastric Epithelioid Leiomyoma and Leiomyosarcoma (Leiomyoblastoma).

机译：胃上皮样平滑肌瘤和平滑肌肉瘤（平滑肌细胞瘤）。

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A series of 127 surgical specimens of epithelioid leiomyomatous tumors of the gastric wall from AFIP files were studied as to biologic behavior, morphogenesis, and histologic features of value in distinguishing benign and malignant variants. These tumors affect middle-aged men primarily and usually present with upper gastrointestinal bleeding or peptic ulcer-like symptoms. They are composed of a mixture of round epithelioid and spindle cells, many of which have clear cytoplasm. The cells are ensheathed by delicate reticular fibers. The presence of a perithelial or glomoid pattern in some tumors suggests a possible relationship to angiomyoma, glomus tumors, and pericytoma. The epithelioid leiomyoma, the benign form, often arises in the mid- and distal stomach. Microscopically, it is recognized by the presence of large epithelioid cells and infrequent mitotic figures. Of 103 epithelioid leiomyomas, only one metastasized. The epithelioid leiomyosarcoma often arises in the proximal stomach and also distally, especially on the posterior wall. Two histologic types of epithelioid leiomyosarcoma are distinguished from the benign epithelioid leiomyoma by the small size of the cells and occasional higher mitotic counts. One sarcoma variant is a small cell caricature of the leiomyoma. The other is more anaplastic, associated with a loss of reticular fibers surrounding the cells and an alveolar arrangement.

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