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Effects of CNS Manipulations on Seizure Latency Following Monomethylhydrazine Administration in the Cat.

机译：中枢神经系统手法对猫咪甲基肼给药后癫痫发作潜伏期的影响。

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The objective of this study was to determine the influence of intracranial electrode placement upon the seizure response to monomethylhydrazine, and to replicate previous findings on the effects of EEG operant conditioning on this response. Thirty cats were studied, 10 in each of 3 different experimental groups. The dependent variable was latency in minutes to generalized motor seizures. The three experimental groups were: (1) an unoperated group, (2) an operated group with cortical and subcortical electrodes, and (3) an operated group as in (2), but provided additionally with sensorimotor rhythm (SMR) EEG operant conditioning. The findings suggested that (1) some aspect of the procedure associated with central nervous system electrode implantation increased susceptibility to MMH-induced seizures, (2) unoperated animals had individual differences in seizure susceptibility, but were significantly more resistant to MMH toxicity than operated animals, and (3) SMR-trained operated animals had individual differences in response to training, but were also more resistant to MMH toxicity.

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作者
Sterman, M. B.; Goodman, S. J.; Fairchild, M. D.;
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年度 1976
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Methyl hydrazines; Seizures(Physiology); Electroencephalography; Central nervous system; Cats; Time; Electrodes; Toxicity; Implantation; Operant conditioning; Monomethyhydrazine; Sensorimotor conditioning; SMR(Sensorimotor rhythm); Seizure latency;

机译：甲基肼;癫痫发作（生理学）;脑电图;中枢神经系统;猫;时间;电极;毒性;植入;操作性调节;单甲基肼;感觉运动调节; smR（感觉运动节律）;癫痫发作潜伏期;

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5. Clinical/pathological assessment and quantitative nuclear magnetic resonance imaging of gene therapy of a naturally occurring CNS disease in the cat. [D] . Vite, Charles Herman. 2003

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6. Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration [O] . Eleni Koutroumanidou, Athanasios Kimbaris, Alexandros Kortsaris, 2013

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7. Comparison of the effects of IVth ventricular administration of some tryptamine analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat. [O] . Shepheard, S. L., Jordan, D., Ramage, A. G. 1994

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Effects of CNS Manipulations on Seizure Latency Following Monomethylhydrazine Administration in the Cat.

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