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首页> 美国政府科技报告 >Effects of Chemotherapy on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-wound Lesion: I. 5-Fluorouracil. II. Alphamethyl-tyrosine. III. Dexamethasone. IV. Simultaneous dexamethasone and 5-Fluorouracil.
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Effects of Chemotherapy on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-wound Lesion: I. 5-Fluorouracil. II. Alphamethyl-tyrosine. III. Dexamethasone. IV. Simultaneous dexamethasone and 5-Fluorouracil.

机译：化疗对大鼠脊髓损伤后脊髓背侧星形胶质细胞密度的影响：I。5-氟尿嘧啶。 II。 α-甲基酪氨酸。 III。地塞米松。 IV。同时使用地塞米松和5-氟尿嘧啶。

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摘要

Rats were lesioned by stab wound in the mid-thoracic spinal cord. Chemotherapy was used in attempt to reduce the post-lesion density of astrocytes. Four experiments were conducted, each with a different chemotherapy regimen: 5-fluorouracil (5-FU), alpha methyl-tyrosine (AMT), dexamethasone, and dexamethasone and 5-FU together. Astrocyte densities were determined by light microscopy. The 5-FU treated cords lead to an apparent 13.1% decrease in astrocyte density; this density is not significantly different from the control cords. AMT therapy resulted in an average astrocyte density that is 11.1% greater than the control (lesion and no chemotherapy). Dexamethasone treatment appeared to have increased astrocyte density by 22% but this had questionable statistical significance. Simultaneous dexamethasone and 5-FU chemotherapy may have produced a small cell density increase. There is no convincing evidence that use of these compounds will reduce the post-lesion glial 'scar'.

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