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首页> 外文期刊>Journal of neural transmission >Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5-HT1A, 5-HT1B, and 5-HT3 receptors in the rat spinal cord.
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Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5-HT1A, 5-HT1B, and 5-HT3 receptors in the rat spinal cord.

机译：背脊神经切断术和血清素能和去甲肾上腺素能系统的选择性损伤对大鼠脊髓中5-HT1A，5-HT1B和5-HT3受体的影响。

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Autoradiographic studies were performed in combination with dorsal rhizotomy or selective lesion of descending serotonergic or noradrenergic systems in an attempt to identify the neuronal cell types endowed with the serotonin 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord. Unilateral sectioning of seven dorsal roots (C4-T2) at the cervical level produced a marked decrease (approximately-75%, 10 days after the surgery) in the binding of [125I]iodozacopride to 5-HT3 receptors in the superficial layers of the ipsilateral dorsal horn, further confirming the preferential location of these receptors on primary afferent fibres. In addition, a significant decrease (approximately 20%) in the binding of [3H]8-OH-DPAT to 5-HT1A receptors and of [125I]GTI to 5-HT1B receptors was also observed in the same spinal area in rhizotomized rats, suggesting that a small proportion of these receptors are also located on primary afferent fibres. The labelling of 5-HT1B receptors was significantly decreased (-12%) in the dorsal horn at the cervical (but not the lumbar) level, and that of 5-HT3 receptors was unchanged in the whole spinal cord in rats whose descending serotonergic projections had been destroyed by 5,7-dihydroxytryptamine. Conversely, the labelling of 5-HT1A receptors was significantly increased in the cervical (+13%) and lumbar (+42%) dorsal horn in 5,7-dihydroxytryptamine-lesioned rats. Similarly, [3H]8-OH-DPAT binding to 5-HT1A receptors significantly increased (+26%) in the lumbar (but not the cervical) dorsal horn in rats whose noradrenergic systems had been lesioned by DSP-4. The labelling of 5-HT1B receptors was also increased (+31% at the cervical level; +17% at the lumbar level), whereas that of 5-HT3 receptors remained unchanged in these animals. These data indicate that complex adaptive changes in the expression of 5-HT1A and 5-HT1B receptors occurred in the rat spinal cord following the lesion of descending monoaminergic systems.
机译：放射自显影研究结合背脊神经切开术或降级血清素能或去甲肾上腺素能系统的选择性病变，以试图鉴定大鼠脊髓中具有5-羟色胺5-HT1A，5-HT1B和5-HT3受体的神经元细胞类型。在颈椎水平单侧切开七个背根（C4-T2）可导致[125I] iodozacopride与5-HT3受体在表层的结合显着减少（手术后10天约为75％）。同侧背角，进一步证实了这些受体在初级传入纤维上的优先位置。此外，在有根茎切除的大鼠的同一脊柱区域，还观察到[3H] 8-OH-DPAT与5-HT1A受体的结合以及[125I] GTI与5-HT1B受体的结合的显着降低（约20％）。 ，表明这些受体的一小部分也位于初级传入纤维上。 5-HT1B受体的标记在子宫颈（但不是腰椎）水平的背角中显着降低（-12％），而5-HT3受体的标记在血清素能投影下降的整个脊髓中没有变化被5,7-二羟基色胺破坏了。相反，在患5,7-二羟基色胺的大鼠的颈背（+ 13％）和腰（+ 42％）背角中，5-HT1A受体的标记显着增加。同样，[3H] 8-OH-DPAT与5-HT1A受体的结合在去甲肾上腺素系统受到DSP-4损伤的大鼠的腰（但不是颈椎）背角中显着增加（+ 26％）。这些动物中5-HT1B受体的标记也增加了（子宫颈水平为+ 31％;腰椎水平为+ 17％），而5-HT3受体的标记则保持不变。这些数据表明5-HT1A和5-HT1B受体表达的复杂的适应性变化发生在单胺能系统下降后的大鼠脊髓中。

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