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A Virally Induced Osteosarcoma in Rats. A Model for Immunological Studies of Human Osteosarcoma.

机译：大鼠病毒性骨肉瘤。人骨肉瘤免疫学研究模型。

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Inoculation of Moloney sarcoma virus into the medullary canal of the tibia in newborn Wistar-Lewis rats resulted in an initially localized osteosarcoma which usually metastasized to the lung and resulted in the death of the animal within four to five weeks. Tumor cells were grown in tissue culture and used as target cells in the assay of lymphocyte-mediated cytotoxicity using a microcytotoxicity and a radioisotope labeling method. Lymphocyte-mediated cytotoxicity was demonstrated throughout the course of the clinical disease as well as in a small number of animals which showed spontaneous regression of their tumors. Serum factors which could block or augment the cellular response were also identified. This model resembles the spontaneous osteosarcoma of humans in many respects and may be useful for studies of the human disease. (Author)

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Friedlander, G. E.; Mitchell, M. S.;
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年度 1976
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Sarcoma virus; Osteogenesis; Tibia; Inoculation; Rats; Cytology; Toxicity; Lymphocytes; Tissue culture; Lung; Neoplasms; Radioactive isotopes; Labeled substances; Immunosuppression; Reprints; Moloney sarcoma virus; Osteosarcoma; Cytotoxicity; Oncogenic viruses; Experimental data;

机译：肉瘤病毒;成骨;胫骨;接种;大鼠;细胞学;毒性;淋巴细胞;组织培养;肺;肿瘤;放射性同位素;标记物质;免疫抑制;重印;莫洛尼肉瘤病毒;骨肉瘤;细胞毒性;致癌病毒;实验数据;

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1. Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1alpha in osteosarcoma. [J] . Z CZ, Luo C, Yang Z, Neoplasma: Journal of Experimental and Clinical Oncology . 2010,第6期

机译：乙酰肝素酶参与人U-2OS骨肉瘤细胞的生长和侵袭，并与骨肉瘤中的缺氧诱导因子1α密切相关。
2. met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma. [J] . De Maria R, Miretti S, Iussich S, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2009,第3期

机译：癌基因激活后，自发犬骨肉瘤可作为人骨肉瘤的合适临床前模型。
3. Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. [J] . Tsukahara T, Kimura S, Ichimiya S Cancer science. . 2009,第1期

机译：Scythe / BAT3调节人骨肉瘤中乳头瘤病毒结合因子诱导的凋亡细胞死亡。
4. Numerical study on MRI RF-induced heating for the trauma screw implanted in three human models [C] . Meiqi Xia, Jianfeng Zheng, Ji Chen IEEE International Symposium on Electromagnetic Compatibility Signal/Power Integrity . 2020

机译：三种人体模型中MRI射频诱导外伤螺钉加热的数值研究
5. Alpha-CaMKII-induced VEGF expression is critical for the growth of human osteosarcoma. [D] . Daft, Paul G. 2014

机译：α-CaMKII诱导的VEGF表达对于人类骨肉瘤的生长至关重要。
6. Longitudinal studies of viral sequence viral phenotype and immunologic parameters of human immunodeficiency virus type 1 infection in perinatally infected twins with discordant disease courses. [O] . C Hutto, Y Zhou, J He, 1996

机译：围产期感染双胞胎疾病进程不一致的人免疫缺陷病毒1型感染的病毒序列病毒表型和免疫学参数的纵向研究。
7. Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma. [O] . Mingjun Guo, Chengkui Cai, Guangyi Zhao, 2014

机译：缺氧促进迁移并通过人骨肉瘤中的HIF-1α活化诱导CXCR4表达。
8. Nonhuman Primate Models for the Study of Hemorrhagic Viral and Rickettsial Diseases. [R] . Beisel, W. R. 1983

机译：用于研究出血性病毒和立克次体病的非人灵长类动物模型。

A Virally Induced Osteosarcoma in Rats. A Model for Immunological Studies of Human Osteosarcoma.

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