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STUDIES ON THE USE OF ELECTRICEEL ACETYLCHOLINESTERASE FOR ANTICHOLINESTERASE AGENT DETECTION

机译：电针乙酰胆碱酯酶用于抗胆碱酯酶检测的研究

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The threshold sensitivity for detection of GB and VX with cholinesterase from electric eel and horse serum is reported. Eel enzyme has ten times the sensitivity of horse enzyme for both agents making it an attractive choice for future kit development. The effect of various buffers, support matrices, and storage conditions on wettability and colorimetric substrate response of eel enzyme tickets was also studied and compared with that of horse serum enzyme tickets. The most wettable and responsive eel enzyme tickets were those prepared from various zwitterionic buffers with glass fiber paper. The use of filter paper and phosphate buffer gave tickets which were difficult to wet and/or which had poor substrate response after extended or accelerated storage.

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作者
Alan Goodman; Hermann Martens;
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年度 1975
页码 1-19
总页数 19
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Agent GB - Detection - Cholinesterase Agent VX - Nerve agents;

机译：代理GB - 检测 - 胆碱酯酶代理VX - 神经代理;

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专利

1. Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease. [J] . Greenblatt HM, Dvir H, Silman I, Journal of Molecular Neuroscience: MN . 2003,第3期

机译：乙酰胆碱酯酶：用于治疗阿尔茨海默氏病的抗胆碱酯酶药物基于结构的药物设计的多方面靶标。
2. A COMPARATIVE STUDY ON THE RELATIONSHIP BETWEEN ACETYLCHOLINESTERASE ACTIVITY AND ACUTE TOXICITY IN DAPHNIA MAGNA EXPOSED TO ANTICHOLINESTERASE INSECTICIDES [J] . LIANE BIEHL PRINTES, AMANDA CALLAGHAN Environmental toxicology and chemistry . 2004,第5期

机译：樟脑干中乙酰胆碱酯酶活性和急性毒性与抗胆碱酯酶杀虫剂关系的比较研究
3. A COMPARATIVE STUDY ON THE RELATIONSHIP BETWEEN ACETYLCHOLINESTERASE ACTIVITY AND ACUTE TOXICITY IN DAPHNIA MAGNA EXPOSED TO ANTICHOLINESTERASE INSECTICIDES [J] . Liane Biehl Printes and Amanda Callaghan Environmental Toxicology and Chemistry . 2004,第5期

机译：樟脑干中乙酰胆碱酯酶活性和急性毒性与抗胆碱酯酶杀虫剂关系的比较研究
4. STRUCTURAL STUDIES ON ACETYLCHOLINESTERASE AND PARAOXONASE DIRECTED TOWARDS DEVELOPMENT OF THERAPEUTIC BIOMOLECULES FOR THE TREATMENT OF DEGENERATIVE DISEASES AND PROTECTION AGAINST CHEMICAL THREAT AGENTS [C] . JOEL L. SUSSMAN, ISRAEL SILMAN NATO Advanced Study Institute on From Molecules to Medicines: Integrating Crystallography in the Fight Against Bioterrorism and Emerging Diseases Affecting Security . 2009

机译：乙酰胆碱酯酶和律酶的结构研究，用于治疗治疗生物分子的治疗去除疾病和化学威胁的保护
5. Conformational studies of acetylcholinesterase at air-water and air-solid interfaces and development of an optical fiber for detection of organophosphorous compounds. [D] . Dziri, Leila. 1999

机译：在空气-水和空气-固体界面的乙酰胆碱酯酶的构象研究以及用于检测有机磷化合物的光纤的开发。
6. Anticholinesterase Activity of Eight Medicinal Plant Species: In Vitro and In Silico Studies in the Search for Therapeutic Agents against Alzheimers Disease [O] . Md Josim Uddin, Daniela Russo, Md Mahbubur Rahman, 2021

机译：八种药用植物物种的抗胆碱酯酶活性：在体外和硅研究中寻找治疗剂免受阿尔茨海默病的治疗剂
7. The Penetration of an Anticholinesterase Agent (Sarin) into Skin. III. A Method for Studying the Rate of Penetration into the Skin of the Living Rabbit11From the Dermatological Research Laboratories of the Department of Dermatology, Harvard Medical School, at the Massachusetts General Hospital, Boston 14, Massachusetts. [O] . Griesemer Robert D., Blank Irvin H., Gould Edith 1958

机译：抗胆碱酯酶剂（沙林）渗透到皮肤中。三，一种研究活体兔皮肤渗透率的方法11，来自马萨诸塞州波士顿市麻萨诸塞州总医院哈佛医学院医学院皮肤病学研究实验室。
8. X-Ray Crystallographic Studies on Acetylcholinesterase and on its Interactionwith Anticholinesterase Agents [R] . Silman, I., Sussman, J. 1995

机译：乙酰胆碱酯酶及其与抗胆碱酯酶相互作用的X射线晶体学研究

STUDIES ON THE USE OF ELECTRICEEL ACETYLCHOLINESTERASE FOR ANTICHOLINESTERASE AGENT DETECTION

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