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首页> 美国政府科技报告 >Transplantation of Hematopoietic and Lymphoid Cells in Mice. H-2 Matched Unrelated Adult Donors Compared with H-2 Mismatched Fetal Donors.
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Transplantation of Hematopoietic and Lymphoid Cells in Mice. H-2 Matched Unrelated Adult Donors Compared with H-2 Mismatched Fetal Donors.

机译：造血和淋巴细胞移植在小鼠体内。 H-2匹配的无关成人捐赠者与H-2不匹配的胎儿捐赠者相比。

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CBA mice were exposed to a supralethal dose of whole body X-irradiation and received transplants of graded, small doses of bone marrow, fetal liver, or fetal liver plus fetal thymus cells obtained from H-2 matched C58 or H-2 mismatched A donors. Survival at 20 days was used to evaluate the ability of the transplants to restore hematopoiesis following the acute radiation injury. Survival at 100 days was used to evaluate the severity of chronic graft-versus-host disease produced by each of the transplants. In the higher dose ranges, cells from fetal donors promoted higher long-term survival rates than did comparable doses of bone marrow cells in both the matched and mismatched strain combinations The most important finding was that cells from mismatched unrelated fetal donors (using a cell dose per kilogram body weight comparable to the number of fetal liver and thymus cells which would be obtainable from one human fetus at 14 weeks of embryonation) promoted higher long-term survival rates than did bone marrow transplants from matched unrelated donors.

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