Characterization of IKBKE as a Breast Cancer Oncogene

机译：IKBKE作为乳腺癌癌基因的表征

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A summary is presented of research performed during three years of a project to further characterize the breast cancer oncogene IKK(epsilon). Two specific aims were pursued. The first was to determine the role of ubiquitination in the upstream regulation of IKK(epsilon). The second aim created a mammary-specific constitutive IKK(epsilon) transgenic mouse model to study the role of IKK(epsilon) in breast cancer initiation and maintenance. The long term goals of this research were to elucidate the mechanism of IKK(epsilon) upstream regulation in order to better understand how it is dysregulated and overexpressed in human breast cancer and also to create a genetic animal model of IKK(epsilon) breast cancer initiation for further study.

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作者
Zhou, A.;
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年度 2011
页码 1-11
总页数 11
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Breast cancer ; Anatomical models ; Cells(Biology) ; Genetics ; Mammary glands ; Neoplasms ; Oncogenic viruses ; Patients ; Transcription(Genetics);

机译：乳腺癌;解剖模型;细胞（生物学）;遗传学;乳腺;肿瘤;致癌病毒;患者;转录（遗传学）;

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1. Functional characterization of PIK3CA as a breast cancer oncogene Review of: 1. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells 2. The oncogenic properties of mutant p110 alpha and p110 beta phosphatidylinositol 3-kinases in human mammary epithelial cells [J] . H. L. Bennett Breast cancer online: BCO . 2006,第7期

机译：PIK3CA作为乳腺癌癌基因的功能表征综述：1.与乳腺癌相关的PIK3CA突变在乳腺上皮细胞中是致癌的。2.突变型p110α和p110β磷脂酰肌醇3激酶在人乳腺上皮细胞中的致癌特性。
2. Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer [J] . Zhen Zhao, Yuanke Li, Hao Liu, Science Advances . 2020,第29期

机译：通过杂种纳米键合并杂交纳米复合物的Ikbke siRNA和Cabazitax的共同递送抑制了三阴性乳腺癌的侵袭性和生长
3. Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2eu oncogene. [J] . Peter Savas, Franco Caramia, Zhi Ling Teo, Current Opinion in Oncology . 2014,第6期

机译：癌基因成瘾性和免疫力：过表达HER2 / neu癌基因的乳腺癌中肿瘤浸润淋巴细胞的临床意义。
4. A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes [C] . 2010 IEEE International Conference on Bioinformatics and Biomedicine . 2010

机译：拷贝数驱动表达的稀疏调控网络揭示了推定的乳腺癌癌基因
5. HER2Delta16: a tumor-specific oncogene that drives tumorigenesis and trastuzumab resistance in HER2+ breast cancer. [D] . Huynh, Felicia C. 2015

机译：HER2Delta16：一种肿瘤特异性癌基因，可驱动HER2 +乳腺癌的肿瘤发生和曲妥珠单抗。
6. Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer [O] . Zhen Zhao, Yuanke Li, Hao Liu, 2020

机译：通过杂种纳米键合并杂交纳米复合物的Ikbke siRNA和Cabazitax的共同递送抑制了三阴性乳腺癌的侵袭性和生长
7. Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene [O] . Boehm Jesse S., Zhao Jean J., Yao Jun, 2007

机译：综合基因组学方法鉴定IKBKE为乳腺癌癌基因

Characterization of IKBKE as a Breast Cancer Oncogene

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