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Resistance to Infection with Schistosoma Mansoni after Immunization with Worm Extracts or Live Cercariae: Role of Cytotoxic Antibody in Mice and Guinea Pigs.

机译：用蠕虫提取物或活尾蚴免疫后对抗血吸虫感染的抗性：细胞毒性抗体在小鼠和豚鼠中的作用。

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Mice and guinea pigs were immunized with adult and cercarial extracts prepared in different ways. Most animals responded by producing moderate to high levels of cytotoxic antibody; but no correlation with resistance to infection could be detected. Initial experiments with a 3M KC1 extract and with cercarial exoantigen produced partial resistance; several attempts to reproduce these results tailed. Mice immunized either by live or attenuated cercariae, while developing very low levels of cytotoxic antibody, were highly resistant to challenge infection. These results are discussed in terms of a failure to induce a cooperative immune mechanism required for the action of cytotoxic antibody. It is suggested that homocytotropic antibodies may play a gatekeeper role by initiating a reaction that promotes the transloction of serum cytotoxic antibodies and cells into the tissue surrounding the migrating schistosomules. (Author)

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Murrell, K. D.; Dean, D. A.; Stafford, E. E.;
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年度 1975
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Schistosoma mansoni; Antigens and antibodies; Cercariae; Mice; Guinea pigs; Immunity; Cytotoxin; Adults; Infections; Immunization; Resistance(Biology); Parasites; Reprints;

机译：曼氏血吸虫;抗原和抗体;尾蚴;小鼠;豚鼠;免疫;细胞毒素;成虫;感染;免疫;抗性（生物学）;寄生虫;重印;

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专利

1. Identification of surface antigens of schistosomula of Schistosoma mansoni recognized by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae. [J] . A J Simpson, S L James, A Sher Infection and immunity . 1983,第2期

机译：曼氏血吸虫血吸虫表面抗原的鉴定，可通过来自慢性感染和暴露于高辐射尾的免疫小鼠的抗体识别。
2. Schistosoma mansoni - NZ rabbit-model: resistance due to infection and active immunization with adult worm antigen [J] . Dely Noronha, Marília S. S. Almeida, Miriam Tendler, Memórias do Instituto Oswaldo Cruz . 1987,第82期

机译：曼氏血吸虫-新西兰兔模型：由于感染和成虫蠕虫抗原主动免疫引起的耐药性
3. Transmission electron microscopic observations on ultrastructural alterations in Schistosoma mansoni adult worms recovered from C57BL/6 mice treated with radiation-attenuated vaccine and/or praziquantel in addition to passive immunization with normal and vaccinated rabbit sera against infection [J] . El-Shabasy Eman A., Reda Enayat S., Abdeen Sherif H., Parasitology Research . 2015,第4期

机译：透射电子显微镜观察从用减毒疫苗和/或吡喹酮治疗的C57BL / 6小鼠中回收的曼氏血吸虫成虫的超微结构改变，以及用正常和接种的兔血清进行被动免疫以预防感染
4. The Protective role of aqueous extract of grape seeds Vitis vinifera in some biochemical parameters and histological changes in methionine for liver, kidney and heart in mice (Mus musculus) [C] . Ahmed Hamid Ahmed, Raghad Hazem alabbasy, Zinah Ibrahim khaleel International Conference on Materials Engineering and Science . 2020

机译：葡萄种子水提取物的保护作用在肝脏，肾脏和小鼠中甲硫氨酸中的一些生化参数和组织学变化中的作用（Mus Musculus）
5. Phenotypic and functional characterization of T-lymphocytes isolated from the liver granulomas of Schistosoma mansoni - infected mice [D] . Ragheb, Samia. 1988

机译：曼氏血吸虫感染小鼠肝肉芽肿中分离到的T淋巴细胞的表型和功能表征
6. Identification of surface antigens of schistosomula of Schistosoma mansoni recognized by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae. [O] . A J Simpson, S L James, A Sher 1983

机译：鉴定曼氏血吸虫血吸虫的表面抗原该抗原被来自慢性感染和暴露于高辐射尾的免疫小鼠的抗体识别。
7. Identification of surface antigens of schistosomula of Schistosoma mansoni recognized by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae [O] . A J Simpson, S L James, A Sher 1983

机译：通过慢性感染免疫抗体和暴露于高度辐照的植物（高度辐照）抗体识别血吸虫曼逊血吸虫的表面抗原

Resistance to Infection with Schistosoma Mansoni after Immunization with Worm Extracts or Live Cercariae: Role of Cytotoxic Antibody in Mice and Guinea Pigs.

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