首页> 美国政府科技报告 >Branched-Chain Amino and Keto Acid Biochemistry and Cellular Biology in Central Nervous System Diseases

【24h】

Branched-Chain Amino and Keto Acid Biochemistry and Cellular Biology in Central Nervous System Diseases

机译：中枢神经系统疾病中支链氨基酸和酮酸生物化学与细胞生物学

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential components of many biochemical and biological processes. There are well-established pathways, such as fatty acid synthesis and oxidation, anabolic use to synthesize new proteins, and anaplerotic use to generate or sustain metabolic intermediate molecules, which we define as 'classical' pathways here. Recently new 'non-classical' roles for BCAAs have been discovered, most notably for leucine. Leucine has been shown to initiate protein synthesis by increasing translational protein complex activities and to suppress feeding behaviors in rats; both phenomena are at least partially mediated through the mammalian target of rapamycin (mTOR) kinase cascade. Our lab previously identified another potential non-classical pathway independent of mTOR, acting through the hypoxia inducible factor (HIF) transcriptional regulatory protein. Our goal for the first line of research for this work was to validate and further elaborate that leucine promotes HIF transcriptional activation through its 2-oxoacid derivative, alpha-ketoisocaproic acid using an in vitro glioma cell line trangenically altered to express a reporter protein for HIF-alpha degradative cycle activity. The 2-oxoacid was found to increase the half-life of the HIF-1alpha component of the HIF-1 heterodimeric complex in normal oxygen conditions and induce secretion of a known HIF-1 transcriptional protein target independent of mTOR activation.

著录项

作者
Henriques, J.;
展开▼
作者单位

展开▼
年度 2009
页码 1-118
总页数 118
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Nervous system diseases ; Proteins ; Theses ; Oxidation ; Transcription(Genetics) ; Central nervous system ; Amino acids ; Biosynthesis ; Fatty acids ; Leucine ; Biochemistry ; Hypoxia;

机译：神经系统疾病;蛋白质;论文;氧化;转录（遗传学）;中枢神经系统;氨基酸;生物合成;脂肪酸;亮氨酸;生物化学;缺氧;

相似文献

外文文献
中文文献
专利

1. D-amino acids in the central nervous system in health and disease. [J] . Fuchs SA, Berger R, Klomp LW, Molecular genetics and metabolism . 2005,第3期

机译：中枢神经系统中的D-氨基酸与健康和疾病有关。
2. Is a clinical application of hybrid liver support systems limited by an initial disorder in cellular amino acid and alpha-keto acid metabolism, rather than by later gradual loss of primary hepatocyte function? [J] . Gerlach JC, Fuchs M, Smith MD, Transplantation: Official Journal of the Transplantation Society . 1996,第2期

机译：混合肝支持系统的临床应用是否受到细胞氨基酸和α-酮酸代谢的初始紊乱，而不是后来逐渐失去原代肝细胞功能的限制？
3. Involvement of glutamate and γ-amino-butyric acid receptor systems on gastric acid secretion induced by activation of κ-opioid receptors in the central nervous system in rats [J] . Sachie Minowa, Satomi Ishihara, Shizuko Tsuchiya, British Journal of Pharmacology . 2003,第6期

机译：谷氨酸和γ-氨基丁酸受体系统参与中枢神经系统中κ阿片受体活化引起的胃酸分泌
4. CHARACTERIZATION OF A D-AMINO ACID OXIDASE MICROBIOSENSOR FOR D-SERINE DETECTION IN THE CENTRAL NERVOUS SYSTEM [C] . Pierre PERNOT, Jean-Pierre MOTHET, Oleg SCHUVAILO, International Solid-State Sensors, Actuators and Microsystems Conference . 2007

机译：中枢神经系统中D-丝氨酸检测D-氨基酸氧化酶微生物传感器的表征
5. Alpha-keto acids, alpha-keto esters, diketopiperazines, 2,5-bis-alkoxy-3,6-dihydropyrazines, and morpholinediones as potential amino acid bioprecursors for delivery of an AMPA antagonist to the central nervous system [D] . Danthi, Satyavijayan Narasimhan. 1997

机译：α-酮酸，α-酮酯，二酮哌嗪，2,5-双烷氧基-3,6-二氢吡嗪和吗啉二酮是潜在的氨基酸生物前体，可将AMPA拮抗剂递送至中枢神经系统
6. Maple syrup urine disease: branched-chain keto acid decarboxylation in fibroblasts as measured with amino acids and keto acids. [O] . J Dancis, J Hutzler, R P Cox 1977

机译：枫糖浆尿病：成纤维细胞中的支链酮酸脱羧用氨基酸和酮酸测量。
7. Families of transmembrane transporters selective for amino acids and their derivatives The information presented in this review was initially prepared for presentation at the FASEB meeting on amino acid transport held in Copper Mountain, Colorado, June 26–July 1, 1999 and was updated in January 2000 following the meeting of the Transport Nomenclature Panel of the International Union of Biochemistry and Molecular Biology (IUBMB) in Geneva, November 28–30, 1999. The system of classification described in this review reflects the recommendations of that panel. [O] . Milton H. Saier Jr 2000

机译：为氨基酸选择性的跨膜转运蛋白家族及其衍生物本综述中提出的信息最初是准备在Colorado铜山，科罗拉多州的氨基酸运输的展示中准备介绍，1999年6月1日至7月1日在2000年1月更新在1999年11月28日至30日，在日内瓦国际生物化学和分子生物学联盟（IUBMB）的交通命名小组会议之后，本综述中描述的分类系统反映了该小组的建议。

Branched-Chain Amino and Keto Acid Biochemistry and Cellular Biology in Central Nervous System Diseases

摘要

著录项

相似文献

相关主题

期刊订阅