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Hyaluronan Tumor Cell Interactions in Prostate Cancer Growth and Survival

机译：透明质酸肿瘤细胞相互作用在前列腺癌的生长和存活

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Hyaluronan is a high molecular weight polyanionic polysaccharide that is increased in more advanced prostate cancers. Tumor cell interaction with this polysaccharide by specific receptors CD44 and RHAMM promote tumor growth, survival and invasion. Work during the last funding period have further defined the mechanism of action of each of these receptors. Studies show that extracellular RHAMM acts a co-receptor for CD44, and the combined action of this receptor complex leads to sustained activation of the ERK 1,2 signal transduction pathway leading to enhance motility and produce patterns of gene transcription that are associated with invasion. Synthetic peptides have also been identified that can bind hyaluronan and inhibit the binding of this polysaccharide to its cognate receptors. These peptides inhibit tumor growth both in vitro and in vivo and the residues important for the activity of the peptides are being defined using nuclear magnetic resonance (NMR). Small molecule libraries that contain compounds which may mimic these peptides are also being interrogated for the ability to inhibit hyaluronan binding to RHAMM and CD44 and to inhibit tumor growth. The goal is to develop new therapeutic strategies for patients with invasive prostate cancer.

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作者
McCarthy, J. B.; Turley, E.;
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年度 2009
页码 1-21
总页数 21
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Prostate cancer ; Polysaccharides ; Transcription(Genetics) ; Peptides ; Receptor sites(Physiology);

机译：前列腺癌;多糖;转录（遗传学）;肽;受体位点（生理学）;

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专利

1. 595 POSTER Insulin-like growth factor-I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer [J] . M.Kawada, H.Inoue, T.Masuda, European Journal of Cancer Supplements . 2006,第12期

机译：595 POSTER从前列腺基质细胞分泌的胰岛素样生长因子-I介导前列腺癌的肿瘤-基质细胞相互作用
2. Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells [J] . Masayoshi Yamaguchi, Satoru Osuka, Tomiyasu Murata, Translational Oncology . 2021,第1期

机译：前列腺癌患者的无进展存活率在肿瘤组织中延长了较高的荧光素表达：过表达的荧光蛋白抑制人前列腺癌细胞中的生长和骨活性
3. Consistent interactions between tumor cell IL-6 and macrophage TNF-alpha enhance the growth of human prostate cancer cells in the bone of nude mouse. [J] . Kim SW, Kim JS, Papadopoulos J, International immunopharmacology . 2011,第7期

机译：肿瘤细胞IL-6和巨噬细胞TNF-α之间的一致相互作用增强了裸鼠骨中人前列腺癌细胞的生长。
4. Cancer Associated Macrophage-Like (CAMLs) Cells in Circulation Predict Progression and Survival in All Stages of Solid Tumors [C] . Cha-Mei Tang International Molecular Medicine Tri-Conference. . 2019

机译：癌症相关的巨噬细胞样（CAML）细胞在循环中预测实体肿瘤的所有阶段的进展和生存
5. Consequences of hyaluronan metabolism on cell cycle progression in prostate tumor growth and metastasis. [D] . Bharadwaj, Alamelu G. 2009

机译：透明质酸代谢对前列腺肿瘤生长和转移中细胞周期进程的影响。
6. Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells [O] . Masayoshi Yamaguchi, Satoru Osuka, Tomiyasu Murata, 2021

机译：前列腺癌患者的无进展存活率在肿瘤组织中延长了较高的荧光素表达：过表达的荧光蛋白抑制人前列腺癌细胞中的生长和骨活性
7. Table 5.4.a.1 Tumor size and histological classification Table 5.4.a.2 Tumor size and cancer stroma relationship Table 5.4.a.3 Tumor size and growth patterns of tumors infiltrating surrounding tissue Table 5.4.a.4 Tumor size and lymphatic invasion Table 5.4.a.5 Tumor size and venous invasion Table 5.4.a.6 Tumor size and intrapancreatic nerve invasion Figure 5.4.a.7 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to histological types Figure 5.4.a.8 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to cancer stroma relationship Figure 5.4.a.9 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to growth patterns of tumors infiltrating surrounding tissue Figure 5.4.a.10 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to lymphatic invasion Figure 5.4.a.11 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to venous invasion Figure 5.4.a.12 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to intrapancreatic nerve invasion [O] . 2007

机译：表5.4.A.1肿瘤大小和组织学分类表5.4.a.2肿瘤大小和癌基质关系表5.4.a.3肿瘤渗透围绕组织的肿瘤大小和生长模式表5.4.a .4肿瘤大小和淋巴侵袭表5.4.a.5肿瘤大小和静脉侵袭表5.4.a.6肿瘤大小和脑内神经侵袭图5.4.a.7胰岛切除术后患者的累积存活根据组织学类型的TS1癌图5.4.a.8根据癌基质关系抑制患者患者的胰腺切除术后图5.4.a.9患者患者胰腺切除术治疗的抑制作用肿瘤渗透围绕组织的生长模式图5.4.A.10根据淋巴侵入胰腺切除术后患者的累积存活图5.4.A.11患者在胰腺切除术后患者的抑制作用静脉侵袭图5.4.A.12根据鳞气院神经入侵的TS1癌患者累积患者的存活

Hyaluronan Tumor Cell Interactions in Prostate Cancer Growth and Survival

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