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Role of Androgen Receptor-Target Genes in Racial Disparity of Prostate Cancer

机译：雄激素受体 - 靶基因在前列腺癌种族差异中的作用

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The award is transferred to the PI 10/1/08. During this short period, we identified a novel androgen responsive element in the promoter region of cyclinB1 that negatively regulates its expression in AR-positive prostate stromal cells. Cyclin B1 expression is maintained by E2F1 in prostate stromal cells in the absence of androgen. Upon stimulation with androgen, E2F1 is displaced from the promoter by E2F4, leading to recruitment of the SMRT co- repressor complex, and repression of cyclin B1 expression. These results strongly indicate cyclin B1 as a bona fide AR target gene negatively controlled by androgen-dependent E2F regulation. Next, we will determine the association between stromal cyclinB1 expression and prostate cancer racial disparity.

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作者
Pearce, P. S.;
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年度 2008
页码 p.1-5
总页数 5
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Prostate cancer ; Cells(Biology) ; Transcription(Genetics) ; Androgens ; Genes ; Receptor sites(Physiology);

机译：前列腺癌;细胞（生物学）;转录（遗传学）;雄激素;基因;受体位点（生理学）;

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专利

1. Androgen Receptor-Target Genes in African American Prostate Cancer Disparities [J] . Bi-DarWang, QiYang, KristinCeniccola, Prostate cancer . 2013,第2期

机译：非裔美国人前列腺癌差异中的雄激素受体靶基因
2. Racial Disparity in Androgen Deprivation Therapy Utilization for Men with High-Risk Prostate Cancer Treated with Intensity-Modulated Radiation Therapy in the Modern Era - A SEER-Medicare Linked Database Analysis [J] . Wang C., Raldow A., King C. R., International Journal of Radiation Oncology, Biology, Physics . 2018,第3Suppla期

机译：在现代时代强度调制的放射治疗的高风险前列腺癌治疗雄激素剥夺治疗利用的种族差异 - Seer-Medicare联系数据库分析
3. Racial variations in COVID‐19 deaths may be due to androgen receptor genetic variants associated with prostate cancer and androgenetic alopecia. Are anti‐androgens a potential treatment for COVID‐19? [J] . Journal of cosmetic dermatology . 2020,第7期

机译：Covid-19死亡的种族变异可能是由于与前列腺癌和雄激素疾病相关的雄激素受体遗传变异。抗雌激素是Covid-19的潜在治疗方法吗？
4. Role of the Androgen Receptor and PI3K/Akt in the Survival of Androgen-Refractory Prostate Cancer Cells [C] . Haojie Huang, Donald J. Tindal International Symposium on Hormonal Carcinogenesis . 2005

机译：雄激素受体和PI3K / AKT在雄激素难治性前列腺癌细胞存活中的作用
5. Prostate cancer cell-derived exosomes enable androgen production by patients derived stem cells: Exploring racial disparity and targeting residual androgen through stem cell-based selective delivery of 3alpha-HSD. [D] . Ranjan, Manish. 2015

机译：前列腺癌细胞衍生的外来体使患者衍生的干细胞能够产生雄激素：通过基于干细胞的3alpha-HSD选择性递送，探索种族差异并靶向残余雄激素。
6. Androgen Receptor-Target Genes in African American Prostate Cancer Disparities [O] . Bi-Dar Wang, Qi Yang, Kristin Ceniccola, 2013

机译：非裔美国人前列腺癌差异中的雄激素受体靶基因
7. Androgen Receptor-Target Genes in African American Prostate Cancer Disparities [O] . Wang Bi-Dar, Yang Qi, Ceniccola Kristin, 2013

机译：非裔美国人前列腺癌差异中的雄激素受体靶基因

Role of Androgen Receptor-Target Genes in Racial Disparity of Prostate Cancer

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