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Effect of Dietary Intervention on Prostate Tumor Development in TRAMP Mice.

机译：膳食干预对TRamp小鼠前列腺肿瘤发展的影响。

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Calorie restriction has been reported to protect rodents from many different cancers. With respect to prostate cancer, a protective effect of energy restriction on development of spontaneous prostate tumors in Lobund- Wistar rats and tumors developing from transplanted prostate tumor tissue or cells in mice and rats has been published. However we have found that in female rodents intermittent caloric restriction is more protective than chronic restriction in preventing transgenic mammary tumor development. Here, we determined how intermittent versus chronic calorie restricted affected development of prostate cancer in transgenic TRAMP mice. A 25% reduction in caloric intake was utilized. Intermittent-restricted mice had significant delay in the age of tumor detection and age at death compared to ad libitum and chronic restricted mice. Serum leptin to adiponectin ratio was lower following intermittent restriction and may indicate an environment that inhibits cell proliferation. In tumor and genital-urinary tissue we are attempting to identify metabolic pathways to target for prevention and/ treatment strategies. In particular we are assessing aspects of the IGF-I, adiponectin and leptin axes. The results of this study provide further evidence that the manner in which calories are consumed has a significant impact of development of some malignancies.

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