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Lycopene Supplementation in the Complementary Management of PSA Failure: A Randomized Placebo-Controlled Trial for Prostate Cancer Survivors

机译：psa失败的补充管理中的番茄红素补充：前列腺癌幸存者的随机安慰剂对照试验

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This is a hypothesis driven, double-blind, randomized, controlled Phase II clinical trial to compare the effect of daily 12-month supplementation of 30mgs lycopene as a single nutrient (Lycopene) or whole-food supplement (Lyc- O-Mato(Registered)) in control of biochemical (PSA) failure in 78 African- American prostate cancer survivors treated initially by radical prostatectomy or radiation. Fasting blood samples to measure free and total PSA, lycopene, isoprostane and essential fatty acids will be collected at baseline, 3- 6- and 12-months. Demographic and medical history, clinical and quality of life (QOL) assessment, dietary assessment, body fat measures and adverse event information will be collected at baseline and all follow-up time-points. Clinical endpoints are >50% PSA reduction from baseline maintained for 2 successive readings 3 months apart, >25% improvement in QOL scores, and control of distant metastasis. Biomarker endpoints are changes in plasma lycopene, and 8- isoprostane-PGF2alpha, a measure of oxidative stress. The effect of the interventions will be analyzed based on evaluable patients as well as by intent- to-treat.

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作者
Ukoli, F. A. ; Kucuk, O. ; Fowke, J. H.;
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年度 2007
页码 1-178
总页数 178
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Metastasis; Prostate cancer; Stresses; Clinical medicine; Nutrients; Oxidation; Hypotheses; Patients; African americans; Survival(Personnel); Placebos; Diet; Prostate gland; Adipose tissue; Fatty acids;

机译：转移;前列腺癌;应激;临床医学;营养素;氧化;假设;患者;非洲裔美国人;生存（人员）;安慰剂;饮食;前列腺;脂肪组织;脂肪酸;

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1. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer|[mdash]|the UK NCRN Pomi-T study [J] . R Thomas, M Williams, H Sharma, Prostate Cancer and Prostatic Diseases . 2014,第2期

机译：一项双盲，安慰剂对照的随机试验，评估了富含多酚的全食食品补充剂对前列腺癌男性PSA进展的影响| mdash |英国NCRN Pomi-T研究
2. ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer [J] . Lane J. Athene, Er Vanessa, Avery Kerry N. L., Cancer prevention research. . 2018,第11期

机译：PROEIEIT：在人前列腺癌的风险增加时，男性中绿茶儿茶素和番茄红素的一期随机安慰剂对照试验
3. Prostate biopsy status and PSA nadir level as early surrogates for treatment failure: analysis of a prostate cancer randomized radiation dose escalation trial. [J] . Pollack A, Zagars G, Antolak J, International Journal of Radiation Oncology, Biology, Physics . 2002,第3期

机译：前列腺活检状态和PSA最低水平是治疗失败的早期替代指标：对前列腺癌随机辐射剂量递增试验的分析。
4. Optimizing Management of Paediatric Diarrhoeal Disease: A Pilot, Factorial, Randomized, Placebo-Controlled Trial of Rapid Enteric Diagnostics and Probiotics [C] . David Goldfarb, Jeffrey Pernica, Andrew Steenhoff, International Molecular Medicine Tri-Conference. . 2016

机译：优化儿科腹泻病管理：快速肠诊断和益生菌的试点，阶乘，随机，安慰剂对照试验
5. Examination of in vitro prostate cancer models supplemented with lycopene, vitamin E and fish oil. [D] . Hurdle, Heather Louise. 2006

机译：补充番茄红素，维生素E和鱼油的体外前列腺癌模型的检查。
6. A double-blind placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer—the UK NCRN Pomi-T study [O] . R Thomas, M Williams, H Sharma, -1

机译：一项双盲安慰剂对照的随机试验评估富含多酚的全食食品补充剂对前列腺癌男性PSA进展的影响-英国NCRN Pomi-T研究
7. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer—the UK NCRN Pomi-T study [O] . Thomas R., Williams M., Sharma H., 2014

机译：一项双盲，安慰剂对照的随机试验，评估富含多酚的全食食品补充剂对前列腺癌男性PSA进展的影响-英国NCRN Pomi-T研究

Lycopene Supplementation in the Complementary Management of PSA Failure: A Randomized Placebo-Controlled Trial for Prostate Cancer Survivors

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