Method for analyzing PSA, and a method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing PSA

• 1. PSA的分析方法、以及使用上述分析方法的前列腺癌和前列腺肥大症的鉴别方法 [P] . 中国专利： CN102317785B . 2015.01.14
• 2. PSA的分析方法、以及使用上述分析方法的前列腺癌和前列腺肥大症的鉴别方法 [P] . 中国专利： CN102317785A . 2012-01-11
• 3. A METHOD FOR ANALYZING PSA, AND A METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA [P] . CA2751400C . 2018-04-17

  机译： PSA的分析方法以及使用该方法分析前列腺肥大的前列腺癌的方法

• 4. Method for analyzing PSA, and a method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing PSA [P] . 美国专利： US9285368B2 . 2016-03-15

  机译： PSA的分析方法以及使用该方法分析PSA的前列腺癌和前列腺肥大的方法

• 5. METHOD FOR ANALYZING PSA, AND A METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA [P] . 美国专利： US2016138118A1 . 2016-05-19

  机译： PSA的分析方法以及使用该方法分析前列腺肥大的前列腺癌的方法

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• 8. Percentage of free prostate-specific antigen (PSA) is a useful method in deciding to perform prostate biopsy with higher core numbers in patients with low PSA cut-off values [O] . Hasan Yilmaz, Seyfettin Ciftci, Ufuk Yavuz, 2015
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• 1. Dynamic contrast-enhanced magnetic resonance imaging of prostate cancer: A review of current methods and applications [J] . Yousef Mazaheri ,Oguz Akin ,Hedvig Hricak . 世界放射学杂志：英文版（电子版） . 2017,第12期
• 2. Evaluation of Methods for Dissemination of Prostate Cancer Survivorship Guidelines: A Survey of Primary Care Providers [J] . Shawn J. Mendonca ,Manijeh Berenji ,Conrad M. Tobert . 泌尿学期刊（英文） . 2013,第3期
• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. A new hybrid method—combined heat flux method with Monte-Carlo method to analyze thermal radiation [J] . Zengwu Zhao ,Daqiang Cang ,Wenfei Wu . 北京科技大学学报：英文版 . 2006,第1期
• 5. f-PSA/t-PSA比值联合前列腺穿刺诊断灰区前列腺癌的临床应用 [C] . 梁阳冰 ,覃斌 ,李长赞 . 2015临床急症经验交流高峰论坛 . 2015
• 6. PSA水平及前列腺穿刺方法对前列腺癌阳性检出率的影响 [A] . 李博文 . 2015