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Targeting of the Nuclear Receptor Coactivator Isoform DELTA3AIB1 in Breast Cancer

机译：靶向核受体辅激活因子异构体DELTa3aIB1在乳腺癌

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AIB1 which stands for Amplified in Breast Cancer , codes for a protein that is a member of the steroid receptor coactivator (SRC) family. AIB1 is amplified in approximately 5-10% of breast cancers and the mRNA and protein overexpressed in >30% of breast cancers. AIB1 interacts with a superfamily of ligand activated nuclear receptors to potentiate transcriptional activity leading to upregulation of downstream target gene expression. An important finding was that an isoform of AIB1 ( Delta3AIB1) is a significantly more effective coactivator of the estrogen receptor than AIB1 and is highly overexpressed in human breast cancer. Prior work in our lab showed that the downregulation of overall levels of AIB1 plus DELTA3AIB1, using a regulatable AIB1 directed ribozyme, resulted in reduced tumor growth in vivo. Overall, these data indicate a major role for AIB1 and its isoform DELTA3AIB1 in breast cancer development and growth. However the relative roles of AIB1 versus the more highly active DELTA3AIB1 in phenotypic changes in the breast has not been determined. In this investigation, we are developing a method to use siRNA directed at DELTA3AIB1 in order investigate its role in breast cancer and as a possible future therapeutic approach to breast cancer.

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作者
Chien, C.;
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年度 2007
页码 1-19
总页数 19
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Receptor sites(Physiology); Estrogens; Nuclear medicine; Transcription(Genetics); Breast cancer; Humans; Proteins; Therapy; Steroids; Targeting; Genes; Sense organs;

机译：受体位点（生理学）;雌激素;核医学;转录（遗传学）;乳腺癌;人类;蛋白质;治疗;类固醇;靶向;基因;感觉器官;

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机译：核激素受体和共激活因子在乳腺癌细胞系BRCA1介导的DNA修复调控中的新作用
2. Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer [J] . Xiuhua Gao, Zafar Nawaz Breast Cancer Research . 2002,第5期

机译：孕酮受体-乳腺癌中的动物模型和细胞信号转导：甾体受体共激活剂和孕激素受体的共抑制因子在乳腺癌中的作用
3. Progesterone signals through membrane progesterone receptors (mPRs) in MDA-MB-468 and mPR-transfected MDA-MB-231 breast cancer cells which lack full-length and N-terminally truncated isoforms of the nuclear progesterone receptor. [J] . Pang Y, Thomas P Steroids: An International Journal . 2011,第9期

机译：孕酮通过MDA-MB-468和mPR转染的MDA-MB-231乳腺癌细胞中的膜孕酮受体（mPRs）发出信号，这些细胞缺乏核孕激素受体的全长和N端截短的亚型。
4. Synthesis and Characterization of DOTA-Coupled Bimeric Y1 Receptors Antagonists for Breast Cancer Targeting [C] . David Chateeet, Renzo Cescato, Beatrice Waser American Peptide Symposium . 2011

机译：乳腺癌靶向乳腺癌靶向乳腺癌拮抗剂的合成与表征
5. The role of nuclear receptor coactivator AIB1/SRC3 in normal and breast cancer stromal functions. [D] . Al-Otaiby, Maram Abdulmohsen. 2012

机译：核受体共激活剂AIB1 / SRC3在正常和乳腺癌基质功能中的作用。
6. The p160 Coactivator PAS-B Motif Stabilizes Nuclear Receptor Binding and Contributes to Isoform-specific Regulation by Thyroid Hormone Receptors [O] . Martin L. Privalsky, Sangho Lee, Johnnie B. Hahm, 2009

机译：p160共激活因子PAS-B母体可稳定核受体的结合并有助于甲状腺激素受体对同工型的调控。
7. 609. Preclinical Evaluation of Bifunctional Short Hairpin RNAs (shRNA) Against Steroid Receptor Coactivator-3/Amplified in Breast Cancer 1 (SRC-3) and Steroid Receptor Coactivator-1 (SRC-1) in Breast Cancers [O] . 2012

机译：609.乳腺癌1（SRC-3）和类固醇受体共粘膜-1（SRC-1）在乳腺癌中对类固醇受体共粘剂-3 /扩增的双功能短发夹RNA（shRNA）的临床前评价

Targeting of the Nuclear Receptor Coactivator Isoform DELTA3AIB1 in Breast Cancer

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