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首页> 美国政府科技报告 >Antigen-Specific Immunotherapy Using Lentivirus-Transduced Hematopoietic Progenitor Cell: A Novel Approach for the Treatment of Metastatis Prostate Cancer
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Antigen-Specific Immunotherapy Using Lentivirus-Transduced Hematopoietic Progenitor Cell: A Novel Approach for the Treatment of Metastatis Prostate Cancer

机译：使用慢病毒转导的造血祖细胞进行抗原特异性免疫治疗：一种治疗转移性前列腺癌的新方法

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This group has completed the goal set for Task 1 ('To examine the immune responses to a model tumor antigen selectively expressed in DCs differentiated in vivo from transduced hematopoietic progenitor cells'). They have: (1) made lentiviral vectors expressing a model tumor antigen influenza hemagglutinin (HA); (2) developed a method to efficiently transduce mouse bone marrow progenitor cells that reconstitute immune and blood systems in irradiated and transplanted mice; (3) demonstrated that the transplanted and transduced cells can persistently present the HA model tumor antigen and stimulate T cell responses; (4) devised a tripartite strategies to mount powerful and specific attack on HA-expressing experimental tumors; and (5) demonstrated the efficacy to eradicate an aggressive pre-established tumor expressing the HA antigen. This study provides a proof-of-principle in immune competent animals models that transplantation of antigen gene transduced hematopoietic progenitor cells adds a new component to achieve potent and sustained antigen-specific immunotherapy of aggressive tumors. Key discoveries by this group and their Hopkins colleagues were published in a leading biomedical research journal Nature Medicine (10: 882).

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