Prenatal Alcohol Exposure Damages Brain Signal Transduction System

机译：产前酒精暴露损害脑信号转导系统

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This final report details the results of our studies. The proposal's overall goal is to uncover biochemical mechanisms that underlie learning and memory. These studies have yielded novel information about the effects of fear conditioning on brain phospholipase C-Betala (PLC-Betala), indicating that PLC-Betala may play an important role in the biochemical processes underlying fear-conditioned learning and memory formation. We have uncovered the molecular basis of the observed association between PLC isozymes and extracellular signal-regulated protein kinase. In addition to increasing our understanding of the biochemical basis of learning and memory, these studies have yielded important information about the neurochemical mechanisms that underlie fear and stress, and, consequently, may provide insight into the neurochemical basis of posttraumatic stress syndrome.

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作者
Caldwell, K. K.;
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年度 2004
页码 1-73
总页数 73
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Brain; Stress(Physiology); Alcoholism; Biochemistry; Enzymes; Memory(Psychology); Fear; Neurochemistry; Exposure(Physiology); Learning; Isozymes; Phospholipids;

机译：脑;应激（生理）;酒精中毒;生物化学;酶;存储器（心理学）;恐惧;神经化学;曝光（生理）;学习;同工酶;磷脂;

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1. PRENATAL ALCOHOL EXPOSURE AND PRENATAL STRESS DIFFERENTIALLY ALTER GLUCOCORTICOID SIGNALING IN THE PLACENTA AND FETAL BRAIN [J] . Lan N., Chiu M. P. Y., Ellis L., Neuroscience: An International Journal under the Editorial Direction of IBRO . 2017,第期

机译：产前酒精暴露和产前应激在胎盘和胎儿脑中差异地改变糖皮质激素信号
2. PRENATAL ALCOHOL EXPOSURE EXERTS SEX-SPECIFIC EFFECTS ON PLACENTAL AND FETAL BRAIN GLUCOCORTICOID SIGNALING [J] . Allan A. M., Solomon E., Cunningham M., Alcoholism: Clinical and experimental research . 2017,第Suppla1期

机译：产前酒精暴露对胎盘和胎儿脑糖皮质激素信号传导发挥性别特异性影响
3. Brain growth spurt-prenatal ethanol exposure and the guinea pig hippocampal glutamate signaling system. [J] . Byrnes ML, Reynolds JN, Brien JF Neurotoxicology and teratology . 2003,第3期

机译：脑生长突增-产前乙醇暴露和豚鼠海马谷氨酸信号系统。
4. A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography [C] . Raksha Raghunathan, Chih-Hao Liu, Manmohan Singh, Conference on Dynamics and Fluctuations in Biomedical Photonics . 2021

机译：使用光学相干血管造影，胎儿脑和母体末端微血管结构变化的比较
5. Postnatal craniofacial and brain dysmorphology induced by prenatal alcohol exposure in C57BL/6 mouse model. [D] . Ai, Huisi. 2013

机译：在C57BL / 6小鼠模型中，由产前酒精暴露引起的产后颅面和脑畸形。
6. PRENATAL ALCOHOL EXPOSURE AND PRENATAL STRESS DIFFERENTIALLY ALTER GLUCOCORTICOID SIGNALING IN THE PLACENTA AND FETAL BRAIN [O] . N. LAN, M. P. Y. CHIU, L. ELLIS, -1

机译：胎盘和胎儿脑中的胎前酒精暴露和胎前压力不同地改变了糖皮质激素的信号
7. Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain [O] . N. Lan, M.P.Y. Chiu, L. Ellis, 2017

机译：产前酒精暴露和产前应激在胎盘和胎儿脑中差异地改变糖皮质激素信号
8. 99HRT Prenatal Alcohol Exposure Damages Brain Signal Transduction Systems [R] . Caldwell, K. K. 2003

机译：99HRT产前酒精暴露损害脑信号转导系统

Prenatal Alcohol Exposure Damages Brain Signal Transduction System

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