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首页> 美国政府科技报告 >Safety, Tolerability, and Antibody Responses in Humans After Sequential Immunization with a PfCSP DNA Vaccine Followed by the Recombinant Protein Vaccine RTS,S/AS02A
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Safety, Tolerability, and Antibody Responses in Humans After Sequential Immunization with a PfCSP DNA Vaccine Followed by the Recombinant Protein Vaccine RTS,S/AS02A

机译：使用重组蛋白疫苗RTs，s / as02a后用pfCsp DNa疫苗连续免疫后人类的安全性，耐受性和抗体反应

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Optimal protection against malaria may require induction of high levels of protective antibody and CD8+ and CD4+ T cell responses. In humans, malaria DNA vaccines elicit CD8+ cytotoxic T cells (CTL) and IFN responses as measured by short-term (ex vivo) ELISPOT assays, and recombinant proteins elicit antibodies and excellent T cell responses, but no CD8+ CTL or CD8+ IFN- producing cells as measured by ex vivo ELISPOT. Priming with DNA and boosting with recombinant pox virus elicits much better T cell responses than DNA alone, but not antibody responses. In an attempt to elicit antibodies and enhanced T cell responses, we administered RTS,S/AS02A, a partially protective Plasmodium falciparum recombinant circumsporozoite protein (CSP) vaccine in adjuvant, to volunteers previously immunized with a P. falciparum CSP DNA vaccine (VCL-2510) and to na 1ve volunteers. This vaccine regimen was well tolerated and safe. The volunteers who received RTS,S/AS02A alone had, as expected, antibody and CD4+ T cell responses, but no CD8+ T cell responses. Volunteers who received PfCSP DNA followed by RTS,S/AS02A had antibody and CD8+ and CD4+ T cell responses (Wang et al., submitted). Sequential immunization with DNA and recombinant protein, also called heterologous prime-boost, led to enhanced immune responses as compared to DNA or recombinant protein alone, suggesting that it might provide enhanced protective immunity.

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