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首页> 美国政府科技报告 >Comparison of Gender Differences in the Effects of Preemptive Ketamine on Percieved Pain in Males and Females Undergoing Selected Ear, Nose, and Throat Surgical Procedures
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Comparison of Gender Differences in the Effects of Preemptive Ketamine on Percieved Pain in Males and Females Undergoing Selected Ear, Nose, and Throat Surgical Procedures

机译：先天性氯胺酮对男性和女性接受选择的耳，鼻，喉手术程序中疼痛疼痛影响的性别差异比较

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Postoperative pain leads to increased morbidity, length of stay, and health care costs. Several studies have shown that preemptively administered N- methyl-D-aspartate (NMDA) antagonists, such as ketamine, are effective in decreasing perception of post operative pain. To date, there have not been any human studies to investigate a gender difference in NMDA receptor antagoism. The purpose of this study was to compare the gender differences in the effects of preemptive ketamine on perceived pain in males and females undergoing selected ENT surgical procedures. This prospective, double-blinded study compared perceived pain in male and female subjects drawn from a convenience sample of patients at a major military medical center. The surgeries there patients were presenting for were tonsillectomy, adenoidectomy, tonsillectomy and adenoidectomy (T&A) and uvulopalatoparyngoplasty (UPPP). 41 subjects were randomly assigned to either a treatment group receiving .lmg/kg ketamine or a control group receiving a placebo of .9% saline. The study drug was administered between induction and incision. Pain perception following surgery was measured using a Numeric Rating Scale (NRS) on arrival to the post anesthesia care unit (PACU), and at four subsequent data points (1, 4, 12, 24 hours after PACU arrival time). ANOVA and Friedman tests were used to analyze the NRS scores. The ANOVA test did not show a significant difference (p = .768) in postoperative pain perception between males and females who received preemptive ketamine. The Friedman test did not show a significant difference (p = .27) in the level of postoperative pain perception within the groups over the five data data collection points.

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