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Biological Function of BRCA1 and Its Regulation by Extracellular Matrix and PTEN in Breast Cancer

机译：BRCa1的生物学功能及其对细胞外基质和pTEN的调控在乳腺癌中的作用

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Inherited mutations in the breast and ovarian cancer susceptibility gene BRCAl are associated with a high risk for developing breast and ovarian cancers. while numerous studies link BRCAl to transcriptional regulation, DNA repair, apoptosis and growth/tumor suppression, the overexpression of the ErbB-2 family of receptor tyronsine kinases has been linked to the development of non- familial or sporadic breast cancer. Activation of HRG signaling, mediated by the binding of HRG to ErbB receptors, has been implicated in the development of aggressive phenotype in breast cancer cells. The mechanisms through which HRC regulates the progression of breast cancer cells to a more invasive or motile phenotype are currently unknown. Our specific aims are: (1) To determine the effect of ECM/integrins on BRCAl expression, phosphorylation and nuclear translocation. (2) To generate inducible stable transfected T47D clones that overexpress BRCAl protein, in order to characterize its biological functions in breast cancer cells. (3) To determine the effect of PTEN on BRCAl phosphorylation.

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作者
Miralem, T. ; Avraham, H.;
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年度 2003
页码 1-9
总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Neoplasms; Receptor sites(Physiology); Growth(Physiology); Phosphorus transferases; Breast cancer; Functions; High rate; Proteins; Deoxyribonucleic acids; Mutations; Genes; Electronic countermeasures; Cells(Biology); Regulations; Suppression; Mammary glands; Phosphorylation; Ovaries; Ovarian cancer; Transcription(Genetics);

机译：肿瘤;受体位点（生理学）;生长（生理学）;磷转移酶;乳腺癌;功能;高比率;蛋白质;脱氧核糖核酸;突变;基因;电子对策;细胞（生物学）;法规;抑制;乳腺;磷酸化;卵巢癌;卵巢癌;转录（遗传学）;

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1. Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer [J] . Sze-Yee Phuah, Lai-Meng Looi, Norhashimah Hassan, Breast Cancer Research . 2012,第6期

机译：三重阴性乳腺癌和PTEN（磷酸酶和硫脲和抗素同源物）损失是早熟和家族性乳腺癌妇女BRCA1种系突变的预测因子，但没有患有孤立的晚期乳腺癌的女性
2. Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families. [J] . Guenard F, Labrie Y, Ouellette G, Familial cancer . 2007,第4期

机译：乳腺癌易感基因PTEN中的种系突变在高风险的非BRCA1 / 2法国加拿大乳腺癌家族中很少见。
3. Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families [J] . Frédéric Guénard, Yvan Labrie, Geneviève Ouellette, Familial Cancer . 2007,第4期

机译：乳腺癌易感基因PTEN中的生殖系突变在高风险的非BRCA1 / 2法国加拿大乳腺癌家族中很少见
4. Elucidating the Effects of Breast Cancer Soluble Factors on Conformation and Mechanics of the Extracellular Matrix [C] . Karin Wang, Roberto C. Andresen, Shengling Hu, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：阐明乳腺癌可溶性因子对细胞外基质构象和力学的影响
5. Regulation of RNA polymerase II by BRCA1, the breast cancer tumor suppressor. [D] . Horwitz, Andrew Aaron. 2006

机译：乳腺癌肿瘤抑制因子BRCA1对RNA聚合酶II的调节。
6. Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer but not in women with isolated late-onset breast cancer [O] . Sze-Yee Phuah, Lai-Meng Looi, Norhashimah Hassan, 2012

机译：三阴性乳腺癌和PTEN（磷酸酶和肌腱同源物）的丢失是早发和家族性乳腺癌妇女BRCA1生殖系突变的预测因素但对于孤立的晚发性乳腺癌妇女则不是
7. Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer [O] . Phuah S. Y., Looi L. M., Hassan N., 2012

机译：三阴性乳腺癌和PTEN（磷酸酶和肌腱同源物）的丢失是早发和家族性乳腺癌妇女BRCA1生殖系突变的预测因素，但对于孤立的晚发性乳腺癌妇女则不是

Biological Function of BRCA1 and Its Regulation by Extracellular Matrix and PTEN in Breast Cancer

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