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首页> 美国政府科技报告 >Development of Retroviral Vectors Targeted to Prostate Cells
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Development of Retroviral Vectors Targeted to Prostate Cells

机译：针对前列腺细胞的逆转录病毒载体的开发

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In order to kill prostate therapy, it is essential to deliver therapeutic genes specifically to the tumor cells. Gene delivery vehicles can be targeted to specific cell types by screening libraries of retroviruses displaying random peptides in the cell-targeting region of the envelope protein (Env) . The retroviruses are screened for their ability to deliver a selectable marker gene to the target cell. A library displaying 2 x 10(7) different peptides within the envelope protein has been screened on the human PC-3 and DU145 prostate cell lines. Several Env proteins have been obtained that can deliver a gene to the Pc-3 cell line. To date, no Env isolate has been successfully identified after screening on the DU145 cell line. Further characterization of the PC-3 targeted Env proteins continues. These proteins promise to be useful reagents in the treatment of prostate cancer.

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