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Role of Insulin-Like Growth Factor (IGF) Binding Proteins (IGFBPs) in IGF-Mediated Tumorigenicity

机译：胰岛素样生长因子（IGF）结合蛋白（IGFBps）在IGF介导的致瘤性中的作用

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The insulin-like growth factor (IGF) system has been shown to play an important role in the development and progression of breast cancer. IGF-l binds with high affinity to a family of proteins called the IGF binding proteins (IGFBPs), which act as natural inhibitors of IGF-l through sequestration from the IGF-l receptor. The purpose of this proposal is the development of IGF antagonists based on the structure of the TGFBPs. Knowledge of the mechanism of IGFBP action is currently unclear, therefore we have taken a photoaffinity labeling approach to identify the IGF binding domains on the IGFBPs. Previous data collected in the lab indicate that the carboxy terminus of IGFBP-2 is involved in high affinity binding to IGF-l; these experiments are being repeated with TGFBP-3 to extend these findings. Current photoaffinity labeling data indicate that the carboxy terminus of the IGFBP-3 protein may be involved in IGF-l binding. This information will be used in the rational design of therapeutic IGF antagonists for use in the treatment of breast and other cancers.

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Harbeson, C. E. ; Rosenzweig, S. A.;
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年度 2003
页码 1-8
总页数 8
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Insulin; Growth(Physiology); Breast cancer; Chelation; Proteins; Cancer; Mammary glands;

机译：胰岛素;生长（生理学）;乳腺癌;螯合作用;蛋白质;癌症;乳腺;

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专利

1. Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secr [J] . Kiess W, Koepf G, Christiansen H, Regulatory peptides. . 1997,第1期

机译：人类神经母细胞瘤细胞通过IGF-I受体在自分泌途径中使用胰岛素样生长因子-I或胰岛素样生长因子-II：IGF，IGF结合蛋白（IGFBP）和IGF受体基因表达的变异性以及IGF和IGFBP secr
2. Influence of droloxifene on plasma levels of insulin-like growth factor (IGF)-I, Pro-IGF-IIE, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 in breast cancer patients. [J] . Helle SI, Anker GB, Tally M, The Journal of Steroid Biochemistry and Molecular Biology . 1996,第3a4期

机译：屈洛昔芬对乳腺癌患者血浆胰岛素样生长因子（IGF）-I，Pro-IGF-IIE，胰岛素样生长因子结合蛋白（IGFBP）-1和IGFBP-3的影响。
3. Roles of insulin-like growth factor-I (IGF-I) and IGF-I binding protein-2 (IGFBP2) and -5 (IGFBP5) in developing chick limbs. [J] . McQueeney K, Dealy CN Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society . 2001,第6期

机译：胰岛素样生长因子-1（IGF-1）和IGF-1结合蛋白2（IGFBP2）和-5（IGFBP5）在雏鸡肢体发育中的作用。
4. Transport of Insulin-like Growth Factor 1 in Intervertebral Disc: Effect of Binding Interactions and Inhomogeneous Distribution of Binding Proteins in Annulus Fibrosus and Nucleus Pulposus [C] . Francesco Travascio, Chun Yuh Huang, Wei Yong Gu ASME summer bioengineering conference;SBC2010 . 2010

机译：胰岛素样生长因子1在椎间盘中的运输：纤维环和髓核中的结合相互作用和结合蛋白的不均匀分布的影响
5. Rice as bioreactor to produce functional human insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP -3) [D] . Cheung, Chun Kai 2007

机译：水稻作为生物反应器，可生产功能性人胰岛素样生长因子-I（IGF-1）和胰岛素样生长因子结合蛋白-3（IGFBP -3）
6. Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery. [O] . D. Y. Lee, D. H. Yang, C. W. Kang, 1997

机译：胃癌患者的血清胰岛素样生长因子（IGFs）和IGF结合蛋白（IGFBP）-3：手术诱导的IGFBP-3蛋白酶活性。
7. Binding Properties of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3), IGFBP-3 N- and C-Terminal Fragments, and Structurally Related Proteins mac25 and Connective Tissue Growth Factor Measured Using a Biosensor [O] . Peter Vorwerk, Bianka Hohmann, Youngman Oh, 2002

机译：胰岛素样生长因子结合蛋白-3（IGFBP-3），IGFBP-3 N-和C-末端片段的结合性质，以及使用生物传感器测量的结构相关蛋白质MAC25和结缔组织生长因子

Role of Insulin-Like Growth Factor (IGF) Binding Proteins (IGFBPs) in IGF-Mediated Tumorigenicity

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