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首页> 美国政府科技报告 >Physiology of Growth Hormone-Releasing Hormone (GHRH) in Breast Cancer
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Physiology of Growth Hormone-Releasing Hormone (GHRH) in Breast Cancer

机译：生长激素释放激素（GHRH）在乳腺癌中的生理学研究

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We hypothesize that GHRH functions as an autocrine/paracrine growth factor in neoplastic breast tissue. To address this hypothesis, we have undertaken a comprehensive examination of the physiology of GHRH in immortalized breast cancer cell lines. We report here the results of the project. The data summarized here indicate that endogenous GHRH acts as a growth factor through activation of MAPK/ERK (in a ras and raf dependent fashion). In addition, the data suggest an anti-apoptotic action of GHRH through suppression of p38 activation of a caspase cascade and consequent inhibition of Bc1-2 cleavage. Activation of an independent Jnk pathway may antagonize the effects of GHRH on the p38 pathway. The data also indicate a possible reciprocal autocrine/ paracrine role for GHRH and somatostatin in the regulation of breast tumor cell growth. Finally, the data support a role for tightly regulated GHRH secretion as an important component in the promotion of breast tumor cell growth. The emerging picture of the pathway by which GHRH promotes growth and inhibits apoptosis in breast cancer cell lines furthers our understanding of the previously demonstrated actions of GHRH antagonists to inhibit breast cancer growth in vitro and in vivo. More importantly, this understanding begins to suggest ways in which GHRH antagonists might fit into therapeutic regimens, as pro-apoptotic agents in their own right or as adjuvant agents supporting the action of traditional anti-neoplastics.

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