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Interactions of Multiple Fluorescent Labels in Biological Sensing

机译:生物传感中多种荧光标记的相互作用

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The long-term goals of this project have been to develop new strategies for the use of oligonucleotides tagged with multiple fluorescent labels as biosensing probes of specific nucleic acid sequences. First, we have designed new classes of fluorescent labels for DNA. Second, we have developed novel modes of interaction between fluorescent labels, leading to color changes on detection of nucleic acids. Finally, we have developed new chemistries for joining DNA strands which can be applied to color-changing strategies. These lines of research led to useful developments in biosensing, and have opened up new areas of investigation for the future.

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