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首页> 美国政府科技报告 >Blocking Vascular Hyperpermeability, the Initiation Step of Tumor Angiogenesis Inhibits Mammary Tumor
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Blocking Vascular Hyperpermeability, the Initiation Step of Tumor Angiogenesis Inhibits Mammary Tumor

机译：阻断血管通透性过高，肿瘤血管生成的起始步骤抑制乳腺肿瘤

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Mammary tumors growth, like most of the other solid tumors, beyond minimal size requires the generation of new blood vesseles and other stromal elements. It is generally agreed that vascular permeability factor / vascular endothelial growth factor (VPF/VEGF) is thought to be largely responsible for the hyperpermeability of tumor blood vessels. Information accumulating from different laboratories including ours has indicated that tumor angiogenesis and stroma formation develop sequentially as increased microvascular permeability triggered by VPF/VEGF secreted mainly by the tumor. This seems to be the key initiation Step of angiogenesis. We have developed three projects related to angiogenesis. (a) We have generated mutant forms of VPF/VEGF into adneovirus vector but initial experiments in animals model did not reproduce the in vitro results as we postulated. (b) We have defined the central role of p53 on regulation of VEGF in breast cancer cells and also evaluated how does p53 modulate the protooncogene c-Src in this pathway. (c) Finally, a project is ongoing to develop an effective anti-tumor angiogenic immunity by means of DC- based vaccination; at the same time it is also directed toward an understanding of the effect of VEGF on DC function. Our hypothesis is that DCs expressing a non-secreted form of VEGF endogenously are capable, of evoking anti-angiogenic immunity in breast cancer, upon injection as a vaccine, in the host.

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