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首页> 美国政府科技报告 >Differential Substrate Profile of the EphA2 Tyrosine Kinase in Non- Transformed and Malignant Breast Epithelia
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Differential Substrate Profile of the EphA2 Tyrosine Kinase in Non- Transformed and Malignant Breast Epithelia

机译：Epha2酪氨酸激酶在非转化和恶性乳腺上皮细胞中的差异底物谱

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The EphA2 receptor tyrosine kinase functions differently in normal and malignant epithelial cells. The goal of the present project was to determine if EphA2 recognizes different substrates in non-transformed and transformed human mammary epithelial cells. To ask this, we utilized a new approach of generating 'unnatural' ATP specificity through site-specific mutation of the EphA2 kinase domain. Although these mutants were successfully generated and expressed in non-transformed and malignant epithelial cells, the EphA2 in these cells was unable to distinguish between standard and 'unnatural.' Consequently, this experimental approach was not able to identify the substrates recognized by EphA2 in normal and malignant cells. Current studies are seeking to identify the reasons why EphA2 fails to distinguish between standard and 'unnatural' ATP as this information could be useful in understanding the regulation of EphA2 enzymatic activity in breast cancer.

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