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首页> 美国政府科技报告 >Positioning Vascularized Composite Allotransplantation within the Spectrum of Solid Organ Transplantation.
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Positioning Vascularized Composite Allotransplantation within the Spectrum of Solid Organ Transplantation.

机译：定位血管复合同种异体移植在实体器官移植的范围内。

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The purpose of this project is to enable more patients to access VCA transplantation. The work in Louisville will focus on using non-invasive imaging techniques that can be used to monitor vessels and nerves in VCA recipients (Aim 6). The goal is to identify changes while there is still time to intervene. Studies are initiated using infrared imaging of ICG dye to study blood perfusion and lymphatic drainage in our hand transplant patients. We are extending our studies of vessel wall thickness using very high resolution ultrasound, and including non-invasive studies of nerve anatomy. In Aim 7 we established a rodent model to study VCA vasculopathy, both with respect to imaging modalities and what factors initiate or exacerbate graft vasculopathy. Initial IR-ICG imaging studies of graft perfusion correlate well with acute graft rejection in our animals. Finally in Aim 8 we will develop standardization of protocols and clinical monitoring and treatment for VCA targeting vascular health. We propose to serve as the central site for the standardization of bioimaging assessment of vasculopathies in hand and face allotransplants. The ultimate goal is to expand the available options for individuals with combat-related injuries in need of complex tissue reconstruction by elevating VCA to the level of an established therapy for use in appropriately selected personnel with severe traumatic tissue loss.

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