• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Effects of Sodium 2-Mercaptoethanesulfonate (Mesna) as a Post-Treatment in Mice Challenged With Phosgene
【24h】

Effects of Sodium 2-Mercaptoethanesulfonate (Mesna) as a Post-Treatment in Mice Challenged With Phosgene

机译：2-巯基乙磺酸钠（mesna）作为后处理对光气攻击小鼠的影响

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of 2-mercaptoethanesulfonate (mesna) as a post-treatment against exposure to a lethal dose of phosgene (CG) were investigated. Mesna appears to be a potential candidate against phosgene-induced injury because it may increase sulfhydryl concentrations, which may reduce cellular injury. Mice were exposed to phosgene, 32 mg/m(3) , or air for 20 minutes. After a 5-minute washout with air, mice were injected interperitoneally (ip) with 0, 334, 834 or 1,667 mg/kg of mesna or phosphate buffered saline (PBS) at 20 minutes, 2, 5, 8 and 11 hours. Survival was assessed every 2 hours for 12 hours and at 24 hours. Lungs were removed and analyzed for wet weight, dry weight, wet/dry ratio, protein, and non-protein sulfhydryls (NPSH).

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号