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Molecular Biological Basis for the Response of Poly (ADP-RIB) polymerase and NAD Metabolism to DNA Damage Caused by Mustard Alkylating Agents.

机译：聚（aDp-RIB）聚合酶和NaD代谢对芥子烷化剂引起DNa损伤的分子生物学基础。

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Poly(ADP-ribose) polymerase (PARP), modifies a variety of nuclear proteins utilizing NAD. DNA is required for the catalytic activity of the enzyme and the activity is dependent upon the presence of strand breaks in this DNA. It has been hypothesized that human skin exposed to mustards may develop blisters due to a generalized lowering of NAD/ATD in exposed skin cells. We have now utilized primary dermal fibroblasts, immortalized fibroblasts, and keratinocytes derived from PARP 4-and their wild type littermates (PARP +1+) and mice to determine the contribution of PARP to SM toxicity. Primary skin fibroblasts from PARP- deficient mice demonstrated increased caspase-3 activity, compared to those from PARP +/+ animals. Propidium Iodide staining and PARP cleavage patterns revealed a SM dose-dependent increase in necrosis in PARP +1+, but not PARP 4- cells. Using immortalized PARP -I- keratinocytes stably transfected with the human PARP cDNA or control cells, the presence of PARP and its activity, inhibited markers of apoptosis in these cells as well.

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Smulson, M. E.;
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年度 2001
页码 1-116
总页数 116
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Enzymes; Deoxyribonucleic acids; Mustard agents; Polymers; Toxicity; Metabolism; Alkylation; Exposure(Physiology); Skin(Anatomy); Epidermis; Vesicants; Apoptosis; Parp(Poly adp ribose polymerase);

机译：酶;脱氧核糖核酸;芥子气;聚合物;毒性;代谢;烷基化;暴露（生理学）;皮肤（解剖学）;表皮;囊泡;细胞凋亡; parp（聚腺苷酸核糖聚合酶）;

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1. Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1. [J] . Conde F, San Segundo PA Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2008,第3期

机译：Dot1在酿酒酵母中对烷基化DNA损伤的响应中的作用：易于出错的聚合酶Polzeta / Rev1对DNA损伤耐受的调节。
2. Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Polζ/Rev1 [J] . Francisco Conde, Pedro A. San-Segundo Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2008,第3期

机译：Dot1在酿酒酵母中对烷基化DNA损伤的响应中的作用：错误错误聚合酶Polζ/ Rev1对DNA损伤耐受性的调节。
3. Balancing repair and tolerance of DNA damage caused by alkylating agents. [J] . Fu D, Calvo JA, Samson LD Nature reviews Cancer . 2012,第2期

机译：平衡烷化剂引起的DNA损伤的修复和耐受性。
4. AC response of a short poly(G)-poly(C) DNA molecular wire [C] . Peiji Zhao, Woolard, D.L. . 2003

机译：聚（G）-聚（C）DNA短分子线的交流响应
5. The role of DNA-damage-response poly (ADP-ribose) polymerases on p53 activation after genotoxic treatment. [D] . Savitsky, Konstantin. 2010

机译：遗传毒性处理后，DNA损伤反应多聚（ADP-核糖）聚合酶对p53活化的作用。
6. Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response [O] . Pei-Ming Chu, Shih-Hwa Chiou, Tsann-Long Su, 2011

机译：DNA N-芥子油烷基化剂BO-1051通过增强和持续的DNA损伤反应增强人类胶质母细胞瘤细胞的放射敏感性
7. Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response [O] . Chen Ming-Teh, Yen Sang-Hue, Chen Yi-Wei, 2011

机译：DNA N-芥子油烷基化剂BO-1051通过增强和持续的DNA损伤反应增强人类胶质母细胞瘤细胞的放射敏感性

Molecular Biological Basis for the Response of Poly (ADP-RIB) polymerase and NAD Metabolism to DNA Damage Caused by Mustard Alkylating Agents.

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