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Exploiting bcl-2 Overexpression in the Chemotherapy of Breast Cancer

机译：利用bcl-2过表达在乳腺癌化疗中的应用

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Previous studies have demonstrated that exposure of estrogen- responsive breast cancer cells in culture to estrogen leads to overexpression of bcl-2. Contrary to the case for apoptosis induced by conventional anticancer drugs, bcl-2 overexpression potentiates apoptosis induction by neocarzinostatin in neural crest tumor cells. We therefore examined the effects of neocarzinostatin on bcl-2- overexpressing breast cancer cells in culture. Unlike the case for neural crest tumor cells, overexpression of bcl-2 in MCF-7 cells did not afford potentiation of apoptosis induction by the reduction-dependent enediyne neocarzinostatin. Instead, MCF-7 cells were protected from apoptosis induced by neocarzinostatin. Two critical mechanistic differences have been discovered to relate to this finding. While bcl-2 overexpression in neural crest tumor cells leads to alteration of glutathione handling in the direction of greater reducing potential, bcl-2 overexpression in MCF-7 cells does not alter cellular redox potential or glutathione handling. Furthermore, neocarzinostatin treatment of neural crest tumor cells results in conversion of Bcl-2 protein to its pro-apoptotic cleavage products. This enzymatic cleavage is induced by caspase 3, an enzyme that is not expressed in MCF-7 cells. Predictably, only apoptosis induced by neocarzinostatin in neural crest tumor cells is inhibited by an inhibitor of caspase 3 activity.

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Schor, N.;
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年度 2000
页码 1-123
总页数 123
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cultures(Biology); Chemotherapy; Estrogens; Breast cancer; Apoptosis; Enzymes; Neoplasms; Response(Biology); Drugs; Handling; Cells(Biology); Oxidation reduction reactions; Antibiotics; Cleavage; Glutathione;

机译：文化（生物学）;化学疗法;雌激素;乳腺癌;细胞凋亡;酶;肿瘤;反应（生物学）;药物;处理;细胞（生物学）;氧化还原反应;抗生素;裂解;谷胱甘肽;

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1. Bcl-2—Enhanced Efficacy of Microtubule-Targeting Chemotherapy through Bim Overexpression: Implications for Cancer Treatment [J] . Amandine Savry, Manon Carre, Raphael Berges, Neoplasia: an international journal for oncology research . 2013,第1期

机译：通过BIM过度表达，BCL-2增强微管靶向化疗的疗效：癌症治疗的影响
2. Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression [J] . Paromita Raha, Scott Thomas, K Ted Thurn, Breast Cancer Research . 2015,第1期

机译：通过逆转Bcl-2过表达，组蛋白去乙酰化酶抑制和他莫昔芬联合可在他莫昔芬耐药的乳腺癌模型中诱导细胞凋亡
3. Clusterin confers resistance to TNF-alphainduced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression [J] . Journal of chemotherapy . 2012,第6期

机译：Clusterin通过NF-κB活化和Bcl-2过表达赋予对TNF-α诱导的乳腺癌细胞凋亡的抗性
4. Clinical Outcome of Breast and Ovarian Cancer Patients Treated after High-Dose Chemotherapy and Autologous Stem Cell Rescue with Theratope (STn-KLH) Cancer Vaccine: Theratope (STn-KLH) Cancer Vaccine following Autologous Transplant [C] . Leona A. Holmberg, Katherine A. Guthrie, Brenda M. Sandmaier Chemical glycobiology . -1

机译：大剂量化学疗法和自体干细胞拯救治疗的Theratope（STn-KLH）癌症疫苗治疗的乳腺癌和卵巢癌患者的临床结果：自体移植后的Theratope（STn-KLH）癌症疫苗
5. Adenoviral overexpression of N-methylpurine DNA glycosylase (MPG) sensitizes breast cancer cells to alkylating agent chemotherapy. [D] . Rinne, Mikael. 2004

机译：N-甲基嘌呤DNA糖基化酶（MPG）的腺病毒过表达使乳腺癌细胞对烷化剂化学疗法敏感。
6. Breast Cancer Special Feature: Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 [O] . Samantha R. Oakes, François Vaillant, Elgene Lim, 2012

机译：乳腺癌的特色：BH3模拟物ABT-737使表达BCL-2的乳腺肿瘤对化学疗法敏感
7. Chemotherapy is one of the therapies for cancer patients that cause some side effects, one of them is nausea and vomiting. Nausea and vomiting are still felt by patients even though they take antiemetics. Nausea dan vomiting can cause fluid and electrolyte imbalance. The aim of this study was to analysis the effect of combination acupressure wristband and antiemetic among chemotherapy induced nausea vomiting (CINV) on breast cancer patients. This research used quasi experimental research method, with a pre-post test with the control group. The sampling techniques was consecutive sampling with 25 respondents both in intervention group and control group. In the intervention group had received an acupressure wristband. CINV measured on the second day until fourth day after chemotherapy. Nausea and vomiting score were measured twice a day by a telemonitoring methode by Rhodes Index Nausea, Vomiting and Retching (INVR) questionaire. Data were analyzed by paired t-test, independent t-test, Wilcoxon test and Mann Whitney. The result of this study showed that acupressure wristband significantly reduce the chemotherapy induced nausea and vomit (p value = 0.000). The use of acupressure wristband combined with antiemetic therapy can significantly decrease chemotherapy induced nausea and vomiting in breast cancer patients. Acupressure wristband recommended for consideration nursing intervention in treating breast cancer patients who experience nausea and vomiting. [O] . Endah Fatma 2018

机译：化疗是癌症患者的疗法之一，导致一些副作用，其中一个是恶心和呕吐。患者仍然感受到恶心和呕吐，即使他们服用助性学。恶心丹呕吐会导致液体和电解质不平衡。本研究的目的是分析组合组合腕带和抑制在乳腺癌患者中的诱导恶心呕吐（CINV）的影响。本研究使用了准实验研究方法，用对照组进行了预先测试。采样技术是在干预组和对照组中进行25名受访者的连续抽样。在干预组中，收到了一名腕带。 Cinv在化疗后第四天测量。通过罗得岛指数恶心，呕吐和转换（INVR）问卷，每天测量恶心和呕吐分数。通过配对的T检验，独立的T检验，Wilcoxon测试和Mann Whitney分析数据。该研究的结果表明，Acuruce腕带显着降低化疗诱导的恶心和呕吐物（P值= 0.000）。使用Acu压抑腕带与止吐疗法相结合，可以显着降低乳腺癌患者诱导的恶心和呕吐。 Acu压痕腕带推荐用于治疗体验恶心和呕吐的乳腺癌患者的护理干预。

Exploiting bcl-2 Overexpression in the Chemotherapy of Breast Cancer

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