Efficacy of Galectin-3C in Mouse Model of Metastatic Breast Cancer

机译：Galectin-3C在转移性乳腺癌小鼠模型中的疗效

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The goal of this research is to evaluate a potential therapeutic agent for breast cancer based on the lectin galectin-3. The hypothesis to be tested is that therapy with an N-terminally truncated form of galectin-3 (galectin-3C) will be efficacious for inhibition of metastases. The overall purpose of the research is to determine the efficacy, safety and mechanism of action of galectin-3C in treatment of metastatic breast cancer. To this end, recombinant galectin-3 was produced from which galectin-3C was derived by collagenase enzyme digestion and affinity chromatography. For ELISA detection of injected galectin-3C in nude mice, chickens were immunized with galectin-3C but the response yielded only low affinity antibody. An alternative detection strategy was developed by metabolically labeling galectin-3 with 35% methionine prior to collagenase cleavage. The maximum tolerated dose of galectin-3C in nude mice at 5 days was determined to be a minimum of (125 mg)kg without adverse effects.

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作者
Jarvis, G. A.;
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年度 1999
页码 1-13
总页数 13
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Enzymes; Proteins; Breast cancer; Therapy; Mice; Antibodies; Dosages; Chickens; Immunization; Laboratory animals; Pharmacokinetics; Blood serum; Immunoassay; Chromatography; Agglutination; Collagenase; Metastasis;

机译：酶;蛋白质;乳腺癌;治疗;小鼠;抗体;剂量;鸡;免疫;实验动物;药代动力学;血清;免疫测定;色谱;凝集;胶原酶;转移;

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Efficacy of Galectin-3C in Mouse Model of Metastatic Breast Cancer

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